T133
Inactin® hydrate
≥98% (HPLC), Anethetic reagent, powder
别名:
Thiobutabarbital sodium salt hydrate
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关于此项目
经验公式（希尔记法）:
C10H15N2NaO2S · xH2O
化学文摘社编号:
分子量:
250.29 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
213-425-3
MDL number:
产品名称
Inactin® hydrate, ≥98% (HPLC)
InChI
1S/C10H16N2O2S.Na/c1-4-6(3)10(5-2)7(13)11-9(15)12-8(10)14;/h6H,4-5H2,1-3H3,(H2,11,12,13,14,15);/q;+1/p-1
InChI key
SLZHLQUFNFXTHB-UHFFFAOYSA-M
SMILES string
[Na+].CCC(C)C1(CC)C([O-])=NC(=S)NC1=O
assay
≥98% (HPLC)
form
powder
drug control
USDEA Schedule IIIN; regulated under CDSA - not available from Sigma-Aldrich Canada
color
light yellow
solubility
H2O: soluble (storage of solutions for more than 8 hours at 4°C is not recommended.)
Quality Level
Application
Inactin® hydrate has been used to anesthetize rats to study stress-induced hypersensitivity and mice to study Cisplatin-induced neuropathy. It has also been used to anesthetize rats to measure the glomerular filtration rate (GFR).
Biochem/physiol Actions
Inactin® is a long-lasting rodent anesthetic with minimal effects on cardiovascular tone and renal output. It exhibits sedative and hypnotic properties.
Legal Information
Inactin is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Eman Y Gohar et al.
Journal of the American Heart Association, 9(10), e015110-e015110 (2020-05-12)
Background The novel estrogen receptor, G-protein-coupled estrogen receptor (GPER), is responsible for rapid estrogen signaling. GPER activation elicits cardiovascular and nephroprotective effects against salt-induced complications, yet there is no direct evidence for GPER control of renal Na+ handling. We hypothesized
Haiyun Qi et al.
Magnetic resonance in medicine, 80(5), 2073-2080 (2018-03-10)
Anesthesia is necessary for most animal studies requiring invasive procedures. It is well documented that various types of anesthesia modulate a wide variety of important metabolic and functional processes in the body, and as such, represent a potential limitation in
J Buelke-Sam et al.
Laboratory animal science, 28(2), 157-162 (1978-04-01)
Rats were anesthetized with pentobarbital, pentobarbital and atropine, inactin [5-ethyl-5-(1'-methyl-propyl)-2-thiobarbiturate], ether and inactin, or urethane. Cardiovascular and arterial acid-base parameters were monitored over a 3-hour period of anesthesia. Heart rate, arterial pressures, and pH progressively decreased with duration of pentobarbital
Maki Niihori et al.
American journal of respiratory cell and molecular biology, 62(2), 231-242 (2019-08-29)
NFU1 is a mitochondrial protein that is involved in the biosynthesis of iron-sulfur clusters, and its genetic modification is associated with disorders of mitochondrial energy metabolism. Patients with autosomal-recessive inheritance of the NFU1 mutation G208C have reduced activity of the
Min-Suk Yoon et al.
BMC neuroscience, 10, 77-77 (2009-07-16)
Cisplatin mediates its antineoplastic activity by formation of distinct DNA intrastrand cross links. The clinical efficacy and desirable dose escalations of cisplatin are restricted by the accumulation of DNA lesions in dorsal root ganglion (DRG) cells leading to sensory polyneuropathy
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