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Merck
CN

T1157

(+)-α-生育酚乙酸酯

BioReagent, suitable for insect cell culture, ~1360 IU/g

别名:

维生素 E 醋酸酯

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关于此项目

经验公式（希尔记法）:
C31H52O3
化学文摘社编号:
58-95-7
分子量:
472.74
PubChem Substance ID:
24899940
eCl@ss:
34058007
UNSPSC Code:
12352205
NACRES:
NA.75
EC Number:
200-405-4
MDL number:
MFCD00072052

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产品名称

(+)-α-生育酚乙酸酯, BioReagent, suitable for insect cell culture, ~1360 IU/g

InChI key

ZAKOWWREFLAJOT-CEFNRUSXSA-N

InChI

1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31-/m1/s1

SMILES string

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(C)=O)c(C)c(C)c2O1

biological source

plant

description

Synthesized from natural α-tocopherol

product line

BioReagent

form

liquid (or semi-solid)

specific activity

~1360 IU/g

mol wt

Mw 472.74 g/mol

purified by

crystallization

technique(s)

cell culture | insect: suitable

color

white to yellow

solubility

chloroform: soluble 50 mg/mL, clear, colorless to yellow

storage temp.

room temp

Quality Level

200

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相关类别

Application

在昆虫细胞培养中用作抗氧化剂。
（+）-α生育酚乙酸酯用于：
  • 作为补充剂，用于培养人胚胎肾细胞（HEK 293），评估其对细胞生长的影响
  • 作为组成成分，用于Dulbecco′s改良Eagle培养基/营养混合物F-12（DMEM / F12），培养永生化软骨细胞系
  • 作为无血清培养基成分，用于培养人类结肠组织器官
  • 试验其对牛关节软骨细胞的抗氧化作用

Biochem/physiol Actions

α-生育酚乙酸酯或维生素E-乙酸酯具有抗氧化性能，减少脂质过氧化。不过，维生素E乙酸酯热分解会导致产生烯烃和苯之类致癌物。

Disclaimer

因为熔点约为 25℃，所以这种制剂通常是油。不发生空气氧化。

General description

α-生育酚乙酸酯是天然存在 α-生育酚的半合成醋酸酯。

hcodes

H413

Hazard Classifications

Aquatic Chronic 4

存储类别

10 - Combustible liquids

wgk

WGK 1

ppe

Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000481858
0000481858
0000464155
0000464155
0000461969

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Optimization of HEK 293 cell growth by addition of non-animal derived components using design of experiments.
Laura Cervera et al.
BMC proceedings, 5 Suppl 8, P126-P126 (2012-03-01)
Michael K Dame et al.
In vitro cellular & developmental biology. Animal, 46(2), 114-122 (2009-11-17)
Normal and neoplastic human colon tissue obtained at surgery was used to establish conditions for organ culture. Optimal conditions included an atmosphere of 5% CO2 and 95% O2; tissue partially submerged with mucosa at the gas interface; and serum-free medium
Michael K Dame et al.
In vitro cellular & developmental biology. Animal, 47(1), 32-38 (2010-11-26)
We have recently shown that a multi-mineral extract from the marine red algae, Lithothamnion calcareum, suppresses colon polyp formation and inflammation in mice. In the present study, we used intact human colon tissue in organ culture to compare responses initiated
Role of vitamin E-acetate on cisplatin induced genotoxicity: An in vivo analysis
Mazumdar M, et al.,
Central European Journal of Biology, 7(2), 334-342 (2012)
Horst Claassen et al.
Cell and tissue research, 319(3), 439-445 (2005-01-26)
Osteoarthritis (OA) is aggravated in menopausal women possibly because of changed serum estrogen levels. Estradiol has been postulated to affect oxidative stress induced by reactive oxygen species (ROS) in articular chondrocytes. We generated ROS in cultured bovine articular chondrocytes by
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