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Merck
CN
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文件

T1157

Sigma-Aldrich

(+)-α-生育酚乙酸酯

BioReagent, suitable for insect cell culture, ~1360 IU/g

别名:

维生素 E 醋酸酯

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About This Item

经验公式（希尔记法）:
C31H52O3
CAS号:
58-95-7
分子量:
472.74
EC 号:
200-405-4
MDL编号:
MFCD00072052
UNSPSC代码:
12352205
eCl@ss:
34058007
PubChem化学物质编号:
24899940
NACRES:
NA.75

生物来源

plant

质量水平

200

描述

Synthesized from natural α-tocopherol

产品线

BioReagent

形式

liquid (or semi-solid)

比活

~1360 IU/g

分子量

Mw 472.74 g/mol

纯化方式

crystallization

技术

cell culture | insect: suitable

颜色

white to yellow

溶解性

chloroform: soluble 50 mg/mL, clear, colorless to yellow

储存温度

room temp

SMILES字符串

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(C)=O)c(C)c(C)c2O1

InChI

1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31-/m1/s1

InChI key

ZAKOWWREFLAJOT-CEFNRUSXSA-N

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相关类别

一般描述

α-生育酚乙酸酯是天然存在 α-生育酚的半合成醋酸酯。

应用

在昆虫细胞培养中用作抗氧化剂。
（+）-α生育酚乙酸酯用于：
  • 作为补充剂，用于培养人胚胎肾细胞（HEK 293），评估其对细胞生长的影响
  • 作为组成成分，用于Dulbecco′s改良Eagle培养基/营养混合物F-12（DMEM / F12），培养永生化软骨细胞系
  • 作为无血清培养基成分，用于培养人类结肠组织器官
  • 试验其对牛关节软骨细胞的抗氧化作用

生化/生理作用

α-生育酚乙酸酯或维生素E-乙酸酯具有抗氧化性能，减少脂质过氧化。不过，维生素E乙酸酯热分解会导致产生烯烃和苯之类致癌物。

注意

因为熔点约为 25℃，所以这种制剂通常是油。不发生空气氧化。

危险声明

H413

预防措施声明

P273 - P501

危险分类

Aquatic Chronic 4

WGK

WGK 1

个人防护装备

Eyeshields, Gloves

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Michael K Dame et al.
In vitro cellular & developmental biology. Animal, 47(1), 32-38 (2010-11-26)
We have recently shown that a multi-mineral extract from the marine red algae, Lithothamnion calcareum, suppresses colon polyp formation and inflammation in mice. In the present study, we used intact human colon tissue in organ culture to compare responses initiated
Optimization of HEK 293 cell growth by addition of non-animal derived components using design of experiments.
Laura Cervera et al.
BMC proceedings, 5 Suppl 8, P126-P126 (2012-03-01)
Dan Wu et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(12), 6349-6355 (2020-03-12)
A combined analytical, theoretical, and experimental study has shown that the vaping of vitamin E acetate has the potential to produce exceptionally toxic ketene gas, which may be a contributing factor to the upsurge in pulmonary injuries associated with using
Role of vitamin E-acetate on cisplatin induced genotoxicity: An in vivo analysis
Mazumdar M, et al.,
Central European Journal of Biology, 7(2), 334-342 (2012)
Horst Claassen et al.
Cell and tissue research, 319(3), 439-445 (2005-01-26)
Osteoarthritis (OA) is aggravated in menopausal women possibly because of changed serum estrogen levels. Estradiol has been postulated to affect oxidative stress induced by reactive oxygen species (ROS) in articular chondrocytes. We generated ROS in cultured bovine articular chondrocytes by
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