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Merck
CN
所有图片(3)

文件

安全信息

T1126

Sigma-Aldrich

甲状腺球蛋白 来源于猪甲状腺腺体

powder

别名:

TG human

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About This Item

CAS号:
EC 号:
MDL编号:
UNSPSC代码:
12352202
NACRES:
NA.61

生物来源

Porcine thyroid

质量水平

形式

powder

分子量

~670 kDa

组成

Iodine, ≥0.3%

氮含量分析

14.0-17.5% total

技术

protein purification: suitable

灰分

≤4%

pI 

4.58

UniProt登记号

储存温度

−20°C

基因信息

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生化/生理作用

甲状腺球蛋白已被证明可调节包括碘化钠同向转运蛋白和Pendrin在内的碘转运蛋白的转录。
甲状腺球蛋白是一种参与碘代谢的主要蛋白质。它由一种储存在甲状腺中的含碘蛋白质组成,当甲状腺受到垂体促甲状腺激素(TSH)的刺激时,就会转化为循环中的甲状腺素。甲状腺球蛋白常被用作产生抗体的载体蛋白。它作为载体蛋白的优势来自于其大量的酪氨酸残基,可以通过重氮反应进行偶联。

其他说明

电泳异构。

制备说明

用水 (20 mg/mL) 复溶时,观察到浑浊溶液和一些不溶物。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

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Sanathana Konugolu Venkata Sekar et al.
Scientific reports, 8(1), 10015-10015 (2018-07-04)
Thyroid plays an important role in the endocrine system of the human body. Its characterization by diffuse optics can open new path ways in the non-invasive diagnosis of thyroid pathologies. Yet, the absorption spectra of tyrosine and thyroglobulin-key tissue constituents
Tanuza Nazmul et al.
Microbiology and immunology, 67(7), 334-344 (2023-05-30)
We first investigated the interactions between several algae-derived lectins and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). We created lectin columns using high-mannose (HM)-type glycan-specific lectins OAA and KAA-1 or core fucose-specific lectin hypninA-2 and conducted binding experiments with SARS-CoV-2. The
Yang Li et al.
International journal of endocrinology, 2021, 9439344-9439344 (2021-08-24)
45 healthy and adult female SD rats were randomly divided into three groups: normal control group, EAT model group, and selenium yeast supplement EAT group. The EAT model rats were induced by subcutaneous injection of porcine thyroglobulin and fed with
Kotaro Kelley et al.
Nature communications, 13(1), 1857-1857 (2022-04-08)
Cryo-FIB/SEM combined with cryo-ET has emerged from within the field of cryo-EM as the method for obtaining the highest resolution structural information of complex biological samples in-situ in native and non-native environments. However, challenges remain in conventional cryo-FIB/SEM workflows, including
L D Kohn et al.
Trends in endocrinology and metabolism: TEM, 12(1), 10-16 (2001-01-04)
Iodide transport by thyrocytes involves porters on the apical and basal surfaces of the cell facing the follicular lumen and bloodstream, respectively. Recent work identifies pendrin as an apical porter and shows that follicular thyroglobulin is a transcriptional regulator of

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