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Merck
CN
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安全信息

T11100P

Sigma-Aldrich

DMT-dT Pharmadite®

别名:

5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxythymidine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite], DMT-dT Phosphoramidite

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About This Item

经验公式（希尔记法）:
C40H49N4O8P
CAS号:
98796-51-1
分子量:
744.81
MDL编号:
MFCD00055063
UNSPSC代码:
41116107
PubChem化学物质编号:
329826643
NACRES:
NA.51

生物来源

non-animal source (no BSE/TSE risk)

质量水平

300

类型

for DNA synthesis

产品线

Proligo Reagents

检测方案

≥99.5% (reversed phase HPLC)
>99.5% (31P-NMR)

形式

powder or granules

技术

oligo synthesis: suitable

杂质

>= 170ppm, none detected (S/N <2.5)
≤0.1% P(III) 100-169ppm (31P-NMR)
≤0.1% single unspecified Imprity (reversed phase HPLC)
≤0.3% dT2 (reversed phase HPLC, DMT-dT cyanoethyl-H-posphonate)
≤0.3% dT3 (reversed phase HPLC, DMT-dT phosphoramidate)
≤0.30 wt. % water content (Karl Fischer)
≤0.5% P(V) -25-99ppm (31P-NMR)
≤3.0 wt. % residual solvent content

颜色

white to off-white

溶解性

soluble, clear

适用性

conforms to structure for H-NMR
conforms to structure for LC-MS

核苷分析

base: deoxythymidine
base protecting group: none
2' protecting group: none
5' protecting group: DMT
deprotection: standard

储存温度

2-8°C

SMILES字符串

COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)N3C=C(C)C(=O)NC3=O)(c4ccccc4)c5ccc(OC)cc5

InChI

1S/C40H49N4O8P/c1-27(2)44(28(3)4)53(50-23-11-22-41)52-35-24-37(43-25-29(5)38(45)42-39(43)46)51-36(35)26-49-40(30-12-9-8-10-13-30,31-14-18-33(47-6)19-15-31)32-16-20-34(48-7)21-17-32/h8-10,12-21,25,27-28,35-37H,11,23-24,26H2,1-7H3,(H,42,45,46)/t35-,36+,37+,53?/m0/s1

InChI key

UNOTXUFIWPRZJX-CEXSRUIHSA-N

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相关类别

一般描述

DMT-dT Pharmadite® is a Pharmadite® product line that represents a new class of standard protected DNA phosphoramidites designed with highly controlled impurity profiles and exceptional overall purity.Pharmadite phosphoramidites are characterized by their exceptional purity and well-defined impurity profile. In particular, they are essentially free fromcontaminants that interfere in coupling reactions, such as other nucleosidic or non-nucleosidic phosphoramidites (P(III)-contaminants). All remainingimpurities in Pharmadite phosphopramidites, if present, are identified, characterized, and quantified. The impact of any such defined impurities on the synthesis of oligonucleotides is well understood and has been shown to be insignificant.

法律信息

Pharmadite is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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