T0909
替诺昔康
NSAID
别名:
4-Hydroxy-2-methyl-N-2-pyridinyl-2H-thieno(2,3-e)-1,2-thiazine-3-carboxamide 1,1-dioxide
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关于此项目
经验公式（希尔记法）:
C13H11N3O4S2
化学文摘社编号:
分子量:
337.37
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
InChI key
LZNWYQJJBLGYLT-UHFFFAOYSA-N
SMILES string
O=C(NC1=NC=CC=C1)C2=C(O)C(SC=C3)=C3S(N2C)(=O)=O
InChI
1S/C13H11N3O4S2/c1-16-10(13(18)15-9-4-2-3-6-14-9)11(17)12-8(5-7-21-12)22(16,19)20/h2-7,17H,1H3,(H,14,15,18)
assay
≥98% (perchloric acid titration)
form
powder
solubility
DMF: 25 mg/mL, clear, yellow-green
Quality Level
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相关类别
Application
Tenoxicam has been used:
- as a non-steroidal anti-inflammatory agent (NSAID) to study its effects on root gravitropism in Arabidopsis thaliana
- as a standard in microanalysis of NSAIDs by spectrophotometry
- to test its effect on surface potential andmembrane fluidity modification in phosphoglyceride monolayers
Biochem/physiol Actions
Non-steroidal antiinflammatory drug (NSAID) with comparatively low risk of renal or hepatic toxicity.
Tenoxicam (TX) possesses antipyretic and analgesic effects. It elicits radical scavenging activity and has the potential to treat enkylosing spondylitis, extra-articular diseases, acute gout, and rheumatic diseases. It is also effective in treating primary dysmenorrhea, postpartum uterine contraction pain, and post-operation backaches. TX is capable of inhibiting prostaglandin synthesis.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 2
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Microanalysis of Selected NSAIDs Using the Spectrophotometric Method
Gumulka P, et al.
Engineering and Technology, 1(2), 211-221 (2020)
Hye Sun Gwak et al.
International journal of pharmaceutics, 236(1-2), 57-64 (2002-03-14)
The effects of vehicles and penetration enhancers on the in vitro permeation of tenoxicam from saturated solutions through dorsal hairless mouse skin were investigated. Various types of vehicles, including ester-, alcohol-, and ether-types and their mixtures, were used as vehicles
Katarzyna Czapla et al.
Langmuir : the ACS journal of surfaces and colloids, 26(5), 3485-3492 (2009-12-25)
Meloxicam, piroxicam, and tenoxicam belong to a highly potent oxicam group of nonsteroidal anti-inflammatory drugs. Whereas the structurally similar oxicams have different pharmacokinetics, treatment efficiency, and adverse effects, their common mechanism of action is the inhibition of a membrane enzyme
S Karthikeyan et al.
The Journal of bone and joint surgery. British volume, 92(1), 77-82 (2010-01-02)
We have carried out a prospective double-blind randomised controlled trial to compare the efficacy of a single subacromial injection of the non-steroidal anti-inflammatory drug, tenoxicam, with a single injection of methylprednisolone in patients with subacromial impingement. A total of 58
Non-steroidal anti-inflammatory drug induced membrane fusion: concentration and temperature effects.
Sutapa Mondal et al.
The journal of physical chemistry. B, 113(51), 16323-16331 (2009-12-04)
Membrane fusion is a critical step in many biological events. The fusion process is always induced by different fusogenic agents of which proteins and peptides form the largest group. The mechanistic details of the fusion process vary depending on the
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