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About This Item
经验公式（希尔记法）:
C6HN3Br4
CAS号:
分子量:
434.71
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥98% (HPLC)
表单
solid
颜色
white
溶解性
DMSO: 28 mg/mL
储存温度
2-8°C
SMILES字符串
Brc1c(Br)c(Br)c2[nH]nnc2c1Br
InChI
1S/C6HBr4N3/c7-1-2(8)4(10)6-5(3(1)9)11-13-12-6/h(H,11,12,13)
InChI key
OMZYUVOATZSGJY-UHFFFAOYSA-N
应用
TBB 用于研究 DNA 损伤介质蛋白 MDC1 的酪蛋白激酶 2 依赖性磷酸化。
生化/生理作用
TBB 与酪蛋白激酶-2 的 Val66 残基结合，抑制 ATP/GTP 的结合。TBB 具有细胞渗透性；在 Jurkat 细胞中诱导半胱天冬酶依赖性细胞凋亡并降解造血谱系细胞特异性蛋白 1。
TBB 是酪蛋白激酶-2 (CK2) 的高度选择性 ATP/GTP 竞争性抑制剂（IC 50 = 900 nM 和 1.6 mM，分别使用大鼠肝脏和重组人 CK2）。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
Eyeshields, Gloves, type N95 (US)
S Sarno et al.
FEBS letters, 496(1), 44-48 (2001-05-10)
The specificity of 4,5,6,7-tetrabromo-2-azabenzimidazole (TBB), an ATP/GTP competitive inhibitor of protein kinase casein kinase-2 (CK2), has been examined against a panel of 33 protein kinases, either Ser/Thr- or Tyr-specific. In the presence of 10 microM TBB (and 100 microM ATP)
Maria Ruzzene et al.
The Biochemical journal, 364(Pt 1), 41-47 (2002-05-04)
Incubation of Jurkat cells with 4,5,6,7-tetrabromobenzotriazole (TBB), a specific inhibitor of protein kinase CK2, induces dose-and time-dependent apoptosis as judged by several criteria. TBB-promoted apoptosis is preceded by inhibition of Ser/Thr phosphorylation of haematopoietic lineage cell-specific protein 1 (HS1) and
J Ross Chapman et al.
EMBO reports, 9(8), 795-801 (2008-06-28)
Mammalian cells respond to DNA double-strand breaks (DSBs) by recruiting DNA repair and cell-cycle checkpoint proteins to such sites. Central to these DNA damage response (DDR) events is the DNA damage mediator protein MDC1. MDC1 interacts with several DDR proteins
The CHARGE syndrome-associated protein FAM172A controls AGO2 nuclear import.
Sallis, et al.
Life science alliance, 6 (2023)
Luca Zinzula et al.
iScience, 25(11), 105354-105354 (2022-11-04)
Ebola virus (EBOV) and Marburg virus (MARV) are highly pathogenic viruses in humans, against which approved antivirals are lacking. During EBOV and MARV infection, coiled-coil mediated oligomerization is essential for the virion protein 35 (VP35) polymerase co-factor function and type
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