T0667
甲氧苄啶 乳酸盐
≥98%
别名:
2,4-二氨基-5-(3,4,5-三甲氧基苄基)嘧啶 乳酸盐
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关于此项目
经验公式（希尔记法）:
C14H18N4O3 · C3H6O3
化学文摘社编号:
分子量:
380.40
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51285203
EC Number:
245-533-1
MDL number:
产品名称
甲氧苄啶 乳酸盐, ≥98%
InChI key
IIZVTUWSIKTFKO-UHFFFAOYSA-N
InChI
1S/C14H18N4O3.C3H6O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-2(4)3(5)6/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2,4H,1H3,(H,5,6)
SMILES string
CC(O)C(O)=O.COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
assay
≥98%
form
powder
storage condition
(Keep container tightly closed in a dry and well-ventilated place.)
color
white
solubility
H2O: soluble 20 mg/mL
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
mycobacteria
mode of action
DNA synthesis | interferes
enzyme | inhibits
storage temp.
2-8°C
Quality Level
Application
甲氧苄啶是最主要的抗细菌剂。 它有二氢叶酸还原酶抑制活性和原核酶选择性。 它在临床上被用来治疗尿道感染、轻度急性前列腺炎、复发性膀胱炎、怀孕期间无症状菌尿和呼吸道感染。 乳酸甲氧苄啶用作选择剂。
Biochem/physiol Actions
甲氧苄啶和磺胺甲恶唑结合，通过阻碍核苷酸合成，干扰细菌细胞叶酸细胞代谢。 甲氧苄啶和原核生物特异性二氢叶酸还原酶（DHFR）结合，抑制二氢叶酸（DHF）和四氢叶酸（THF）还原。THF是胸腺嘧啶合成途径基本前体，干扰该途径，抑制细菌DNA合成。
General description
化学结构：嘧啶
Other Notes
保存于密闭容器内，置于干燥通风处。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Repr. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Nucleic acids research, 39(Database issue), D1035-D1041 (2010-11-10)
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