T0656
1,3,4,6-四氯-3α,6α-二苯基甘脲
别名:
Iodo-Gen®, NSC 4462
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关于此项目
经验公式（希尔记法）:
C16H10Cl4N4O2
化学文摘社编号:
分子量:
432.09
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352101
MDL number:
InChI
1S/C16H10Cl4N4O2/c17-21-13(25)23(19)16(12-9-5-2-6-10-12)15(21,11-7-3-1-4-8-11)22(18)14(26)24(16)20/h1-10H
SMILES string
ClN1C(=O)N(Cl)C2(N(Cl)C(=O)N(Cl)C12c3ccccc3)c4ccccc4
InChI key
FJQZXCPWAGYPSD-UHFFFAOYSA-N
storage temp.
2-8°C
Quality Level
Application
用作氧化剂的放射性碘化用碘化试剂
用于氯胺-T 比较研究的试剂
用于氧化咪唑的试剂
用于氯胺-T 比较研究的试剂
用于氧化咪唑的试剂
Legal Information
Iodo-Gen is a registered trademark of Pierce Biotechnology, Inc.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Ulla Lund et al.
American journal of physiology. Renal physiology, 284(6), F1226-F1234 (2003-03-07)
The size and charge-selective properties of the glomerular barrier are partly controversial. Glomerular sieving coefficients (theta) for proteins have rarely been determined noninvasively before in vivo. Therefore, theta was assessed vs. glomerular filtration rate (GFR; (51)Cr-EDTA clearance) in intact rats
Bernard M Tijink et al.
European journal of nuclear medicine and molecular imaging, 36(8), 1235-1244 (2009-03-05)
The human monoclonal antibody (MAb) fragment L19-SIP is directed against extra domain B (ED-B) of fibronectin, a marker of tumour angiogenesis. A clinical radioimmunotherapy (RIT) trial with (131)I-L19-SIP was recently started. In the present study, after GMP production of (124)I
Miro J Eigenmann et al.
The Journal of physiology, 595(24), 7311-7330 (2017-09-30)
For therapeutic antibodies, total tissue concentrations are frequently reported as a lump sum measure of the antibody in residual plasma, interstitial fluid and cells. In terms of correlating antibody exposure to a therapeutic effect, however, interstitial pharmacokinetics might be more
Th M Behr et al.
Nuklearmedizin. Nuclear medicine, 41(2), 71-79 (2002-05-07)
Simple and reliable methodologies for radioiodination of proteins and peptides are described. The labeling systems are easy to assemble, capable of radioiodinating any protein or, with slight modifications, also peptide (molecular mass 1000-300,000) from kBq to GBq levels of activity
M R Zalutsky et al.
Nuclear medicine and biology, 26(7), 781-790 (2000-01-11)
Monoclonal antibody (MAb) internalization can have a major effect on tumor retention of radiolabel. Two anti-HER-2/neu MAbs (TA1 and 520C9) were radioiodinated using the iodogen, N-succinimidyl 5-iodo-3-pyridinecarboxylate (SIPC), and tyramine-cellobiose (TCB) methods. Paired-label studies compared internalization and cellular processing of
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