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检测方案
≥97.0% (HPLC)
形式
powder
技术
cell culture | mammalian: suitable
储存温度
−20°C
SMILES字符串
N[C@@H](Cc1ccc(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O
InChI
1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1
InChI key
HZCBWYNLGPIQRK-LBPRGKRZSA-N
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应用
3,3',5'-三碘 L -甲状腺原氨酸已被用作细胞培养基的补充剂，用于从人类多能干细胞生成少突胶质细胞谱系细胞。它也被用作 体外培养上皮组织的补充剂。
生化/生理作用
3,3',5'-三碘 L -甲状腺原氨酸 (T3) 是由甲状腺产生的一种内分泌激素，在细胞水平上被认为是一种活跃的甲状腺激素。 T3 与染色质中非组蛋白的相互作用激发了甲状腺激素的活性。甲状腺激素可调节组织的分化和发育，并影响多个代谢过程。在甲状腺功能减退症中，循环T3激素水平降低。
rT3 在新生大鼠心肌细胞中，抑制其他甲状腺激素类似物产生钠电流的增加。将三碘苏氨酸（T3）与 rT3 的比率作为胰岛素抵抗指标，进行了研究。
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
涉药品监管产品
Enrique Pimentel
Hormones Growth Factors & Oncogenes, 219-219 (1987)
An Jacobs et al.
Thyroid : official journal of the American Thyroid Association, 29(4), 480-492 (2019-02-15)
Non-thyroidal illness (NTI), which occurs with fasting and in response to illness, is characterized by thyroid hormone inactivation with low triiodothyronine (T3) and high reverse T3 (rT3), followed by suppressed thyrotropin (TSH). Withholding supplemental parenteral nutrition early in pediatric critical
Reporting on methods to generate and purify rodent and human oligodendrocytes from different sources
MehdiDjelloul
Stem Cell Research, 20, 58-66 (2017)
Victor R. Preedy
Handbook of Behavior, Food and Nutrition, 2109-2109 (2011)
Tatsuya Kunisue et al.
Analytical chemistry, 83(1), 417-424 (2010-12-03)
Thyroid hormones (THs) play critical roles in the regulation of growth and development, including brain development, in both humans and animals. Until recently, TH levels were assayed with measurements in serum, using immunoassay (IA)-based methods. IA methods are sensitive but
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