推荐产品
生物来源
human
重组
expressed in CHO cells
方案
≥98% (SDS-PAGE)
表单
lyophilized
分子量
monomer 46 kDa by calculation
包装
pkg of 100 μg
杂质
<0.06 EU/μg endotoxin, tested
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... PDCD1(5133)
一般描述
Programmed Death-1 (PD-1, CD279) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T-cells, B-cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T-cell proliferation and production of IL-1, IL-4, IL-10 and IFN-γ. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.
外形
Lyophilized from 0.2 μm-filtered solution in PBS.
重悬
Reconstitute at 100 μg/mL in sterile PBS.
其他说明
The extracellular domain of human CD279 [PD-1] (aa 25-167) is fused to the N-terminus of the Fc region of human IgG1.
储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门