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生物来源
Toxoplasma gondii
重组
expressed in E. coli
检测方案
>95% (SDS-PAGE)
形式
lyophilized
分子量
~20 kDa by SDS-PAGE
包装
pkg of 10 μg
储存条件
avoid repeated freeze/thaw cycles
杂质
<0.01 EU/μg endotoxin, tested
颜色
white
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
Toxoplasma gondii ... PRF(7900190)
生化/生理作用
Profilin is a protozoan parasite protein. It activates toll-like receptor 11 (TLR11), which is an intracellular receptor localized on the endoplasmic reticulum (ER). TLR11 acts as an innate immune sensor for T. gondii profilin (TgPRF).The 12 membrane-spanning ER-resident protein UNC93B1 directly binds TLR11 and control the activation of dendritic cells in response to profilin (Toxoplasma gondii) and parasitic infection in vivo. TLR12 also has an ability to interact with (TgPRF). TLR12 is adequate for recognizing profilin in plasmacytoid dendritic cells (pDCs), whereas TLR11 and TLR12 are both needed in macrophages and conventional DCs. In contrast to TLR11, TLR12-deficient mice fail to resist T. gondii infection.
外形
Lyophilized from PBS.
重悬
Reconstitute with 100 μL deionized water.
其他说明
Recombinant profilin (Toxoplasma gondii) (aa 1-163).
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii.
Koblansky A A, et al.
Immunity, 38(1), 119-130 (2013)
UNC93B1 is essential for TLR11 activation and IL-12 dependent host resistance to Toxoplasma Gondii.
Pifer R, et al.
The Journal of Biological Chemistry, M110-M110 (2010)
Erik W Martin et al.
Science signaling, 13(620) (2020-02-27)
The complex signaling dynamics of transcription factors can encode both qualitative and quantitative information about the extracellular environment, which increases the information transfer capacity and potentially supports accurate cellular decision-making. An important question is how these signaling dynamics patterns are
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