生物来源
mouse
重组
expressed in HEK 293 cells
标签
FLAG® tagged
检测方案
>95% (SDS-PAGE)
形式
lyophilized
分子量
~34 kDa by SDS-PAGE
包装
pkg of 10 μg
储存条件
avoid repeated freeze/thaw cycles
杂质
<0.02 EU/μg endotoxin, tested
颜色
white
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
mouse ... Tnfsf13(69583)
一般描述
APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. APRIL is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the N-terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells.
外形
Lyophilized from PBS.
重悬
Reconstitute with 100 μL deionized water.
其他说明
The extracellular domain of mouse APRIL (aa 88-232) is fused at the N-terminus to mouse ACRP30headless (aa 18-110) and a FLAG®-tag.
法律信息
FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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