生物来源
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
检测方案
>95% (SDS-PAGE)
形式
lyophilized
分子量
~50 kDa by SDS-PAGE
包装
pkg of 10 μg
杂质
<0.01 EU/μg endotoxin, tested
颜色
white
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 ... fliC (STM1959)
一般描述
编码的鞭毛蛋白丝含有55 kDa单体。
鞭毛蛋白（FliC）是一种亚单位蛋白，它聚合形成细菌鞭毛丝。蛋白质有四个结构域（D0、D1、D2、D3）。
生化/生理作用
它还刺激促炎介质的产生：一氧化氮、白细胞介素1 （IL-1）、IL-6、IL-8和肿瘤坏死因子α。
鞭毛蛋白（FliC）能通过TLR5（toll样受体5）激活先天免疫系统，是一种重要的促炎分子。FliC还诱导抗体的产生，并被CD4+ T细胞鉴定为抗原。
外形
自PBS冻干。
重悬
用100 μL去离子水重组。
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways.
Zeng H, et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology, 290(1), G96-G108 (2006)
FliC-specific CD4+ T cell responses are restricted by bacterial regulation of antigen expression.
Cummings LA
Journal of Immunology, 174, 7929-7938 (2005)
Mucosal administration of flagellin induces innate immunity in the mouse lung.
Honko A N and Mizel S B
Infection and Immunity, 72(11), 6676-6679 (2004)
In vivo, fliC expression by Salmonella enterica serovar Typhimurium is heterogeneous, regulated by ClpX, and anatomically restricted.
Cummings LA
Molecular Microbiology, 61, 795-809 (2006)
Laís Rossi Perazza et al.
The Journal of nutrition, 150(10), 2673-2686 (2020-09-05)
Recent meta-analyses suggest that the consumption of fermented dairy products reduces type 2 diabetes and cardiovascular disease (CVD) risk, although the underlying mechanisms remain unclear. We evaluated whether dairy protein products modulated gut microbiota and cardiometabolic features in mouse models
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