产品名称
鼠伤寒沙门氏菌鞭毛蛋白, >95% (SDS-PAGE)
biological source
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
assay
>95% (SDS-PAGE)
form
lyophilized
mol wt
~50 kDa by SDS-PAGE
packaging
pkg of 10 μg
impurities
<0.01 EU/μg endotoxin, tested
color
white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 ... fliC (STM1959)
Biochem/physiol Actions
它还刺激促炎介质的产生：一氧化氮、白细胞介素1 （IL-1）、IL-6、IL-8和肿瘤坏死因子α。
鞭毛蛋白（FliC）能通过TLR5（toll样受体5）激活先天免疫系统，是一种重要的促炎分子。FliC还诱导抗体的产生，并被CD4+ T细胞鉴定为抗原。
General description
编码的鞭毛蛋白丝含有55 kDa单体。
鞭毛蛋白（FliC）是一种亚单位蛋白，它聚合形成细菌鞭毛丝。蛋白质有四个结构域（D0、D1、D2、D3）。
Physical form
自PBS冻干。
Preparation Note
用100 μL去离子水重组。
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
In vivo, fliC expression by Salmonella enterica serovar Typhimurium is heterogeneous, regulated by ClpX, and anatomically restricted.
Cummings LA
Molecular Microbiology, 61, 795-809 (2006)
Laís Rossi Perazza et al.
The Journal of nutrition, 150(10), 2673-2686 (2020-09-05)
Recent meta-analyses suggest that the consumption of fermented dairy products reduces type 2 diabetes and cardiovascular disease (CVD) risk, although the underlying mechanisms remain unclear. We evaluated whether dairy protein products modulated gut microbiota and cardiometabolic features in mouse models
Mucosal administration of flagellin induces innate immunity in the mouse lung.
Honko A N and Mizel S B
Infection and Immunity, 72(11), 6676-6679 (2004)
FliC-specific CD4+ T cell responses are restricted by bacterial regulation of antigen expression.
Cummings LA
Journal of Immunology, 174, 7929-7938 (2005)
Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways.
Zeng H, et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology, 290(1), G96-G108 (2006)
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