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产品名称
Progranulin mouse, recombinant, expressed in HEK 293 cells, FLAG® tagged, >95% (SDS-PAGE)
生物来源
mouse
重组
expressed in HEK 293 cells
标签
FLAG® tagged
方案
>95% (SDS-PAGE)
表单
liquid
分子量
~70 kDa by SDS-PAGE
包装
pkg of 10 μg
制造商/商品名称
Sigma-Aldrich
储存条件
avoid repeated freeze/thaw cycles
浓度
≥0.2 mg/mL
杂质
<0.1 EU/μg endotoxin, tested
颜色
clear
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
mouse ... Grn(14824)
一般描述
Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer′s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
外形
Solution in PBS.
其他说明
Signal peptide and mouse progranulin (aa 1-589) are fused at the C-terminus to a FLAG®-tag.
法律信息
FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
Masato Kanazawa et al.
Brain : a journal of neurology, 138(Pt 7), 1932-1948 (2015-04-04)
In the central nervous system, progranulin, a glycoprotein growth factor, plays a crucial role in maintaining physiological functions, and progranulin gene mutations cause TAR DNA-binding protein-43-positive frontotemporal lobar degeneration. Although several studies have reported that progranulin plays a protective role
Lorenz Thurner et al.
Digestive diseases and sciences, 59(8), 1733-1742 (2014-03-05)
Recently, we identified neutralizing autoantibodies against progranulin (PGRN) in a wide spectrum of rheumatic diseases including cases with enteropathic spondylarthritis. PGRN is a secreted protein with strong anti-inflammatory effects, believed to be mediated by the direct inhibition of TNF receptors
Michael J Smout et al.
PLoS pathogens, 11(10), e1005209-e1005209 (2015-10-21)
Infection with the human liver fluke Opisthorchis viverrini induces cancer of the bile ducts, cholangiocarcinoma (CCA). Injury from feeding activities of this parasite within the human biliary tree causes extensive lesions, wounds that undergo protracted cycles of healing, and re-injury
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