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生物来源
human
重组
expressed in E. coli
标签
His tagged
方案
>90% (SDS-PAGE)
表单
lyophilized
分子量
~25 kDa by SDS-PAGE
包装
pkg of 10 μg
储存条件
avoid repeated freeze/thaw cycles
杂质
<1 EU/μg endotoxin, tested
颜色
white
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... GPX1(2876)
一般描述
GPX1 (glutathione peroxidase 1) is a selenoprotein and the gene is mapped to human chromosome 3p21.3. It is present in the cytoplasm and is widely expressed.
生化/生理作用
GPX1 (glutathione peroxidase 1) is responsible for scavenging free radicals and derivatives. GPXs reduces lipid hydroperoxides to the corresponding alcohols as well as free hydrogen peroxide to water. Mutations in the GPX1 gene are associated with nonalcoholic fatty liver disease (NAFLD) susceptibility. Mutation in GPX1 at C594T is linked with oxidative stress-associated disorders, including prostate cancer and bladder cancer.
外形
Lyophilized from 55 mM TRIS-HCl, pH 8.2, containing 150 mM NaCl, 1 mM DTT.
重悬
Reconstitute with 100 μL deionized water.
其他说明
Human GPX1 (aa 1-201) is fused at the C-terminus to a His-tag.
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
历史批次信息供参考:
Glutathione Peroxidase Level in Patients with Vitiligo: A Meta-Analysis.
Xiao BH, et al.
BioMed Research International, 2016, 3029810-3029810 (2016)
Association of polymorphisms of adiponectin gene promoter-11377C/G, glutathione peroxidase-1 gene C594T, and cigarette smoking in nonalcoholic fatty liver disease.
Zhang CX, et al.
Journal of the Chinese Medical Association : JCMA, 79, 195-195 (2016)
Manon Ros et al.
Nature cell biology, 22(11), 1371-1381 (2020-10-21)
Tumour growth and invasiveness require extracellular matrix (ECM) degradation and are stimulated by the GALA pathway, which induces protein O-glycosylation in the endoplasmic reticulum (ER). ECM degradation requires metalloproteases, but whether other enzymes are required is unclear. Here, we show
Influence of Gender and SNPs in GPX1 Gene on Biomarkers of Selenium Status in Healthy Brazilians.
Donadio JL, et al.
Nutrients, 8, E81-E81 (2016)
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