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生物来源
mouse
重组
expressed in HEK 293 cells
标签
FLAG® tagged
方案
>90% (SDS-PAGE)
表单
liquid
分子量
~22 kDa by SDS-PAGE
包装
pkg of 50 μg
储存条件
avoid repeated freeze/thaw cycles
浓度
≥0.2 mg/mL
杂质
<0.1 EU/μg endotoxin, tested
颜色
clear
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
mouse ... Tnfsf18(240873)
一般描述
GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.
外形
Solution in 10 mM glycine, pH 10.0.
其他说明
The extracellular domain of mouse GITRL (aa 45-173) is fused at the N-terminus to a FLAG®-tag.
法律信息
FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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