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生物来源
mouse
重组
expressed in E. coli
标签
His tagged
检测方案
>90% (SDS-PAGE)
形式
liquid
分子量
~45 kDa by SDS-PAGE
包装
pkg of 50 μg
储存条件
avoid repeated freeze/thaw cycles
浓度
≥0.2 mg/mL
杂质
<1 EU/μg endotoxin, tested
颜色
clear
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
mouse ... Clu(12759)
一般描述
Clusterin is expressed in all tissues. However, it is strongly expressed in the central nervous system and plasma. Clusterin mainly protects against heat and other stress. It is also referred as chaperone protein and stress-inducible biomarker. Clusterin exists in two isoforms, one is a secretory form and other is a nuclear form. The secreted form of the protein is a 80kDa disulfide-linked heterodimer of α and β subunits (produced by internal cleavage). The alternatively spliced inactive cytosolic form is changed to a truncated mature nuclear isoform via ionizing irradiation.
生化/生理作用
Clusterin is involved in tissue remodeling, cell death, lipid transport, complement-associated cell lysis, cancer and neurological damage. It is strongly expressed in Alzheimer′s and treatment-resistant cancer. High levels of clusterin are observed in ischemic heart disease and diabetic conditions. It also protects kidney from fibrosis. Nuclear form of clusterin works as a pro-death signal, and suppresses cell growth and survival. The secreted form of clusterin has extracellular chaperone and anti-apoptotic activities.
外形
Solution in 55 mM TRIS-HCl, pH 8.2, containing 150 mM NaCl.
其他说明
Mouse nuclear clusterin (aa 22-448) is fused at the C-terminus to a His-tag.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Clusterin Modulates Allergic Airway Inflammation by Attenuating CCL20-Mediated Dendritic Cell Recruitment.
Hong GH, et al.
Journal of Immunology, 196, 2021-2021 (2001)
Clusterin is a potential lymphotoxin beta receptor target that is upregulated and accumulates in germinal centers of mouse spleen during immune response.
Afanasyeva MA, et al.
PLoS ONE, 9, e98349-e98349 (2014)
Clusterin/ApoJ enhances central leptin signaling through Lrp2-mediated endocytosis.
Byun K, et al.
The Embo Journal, 15, 801-801 (2014)
Synthesis and functional analyses of nuclear clusterin, a cell death protein.
Leskov KS, et al.
The Journal of Biological Chemistry, 278, 11590-11590 (2003)
Ca2+ depletion induces nuclear clusterin, a novel effector of apoptosis in immortalized human prostate cells.
Caccamo AE, et al.
Cell Death and Differentiation, 12, 101-101 (2005)
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