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生物来源
mouse
重组
expressed in E. coli
方案
≥90% (SDS-PAGE)
表单
liquid
分子量
23.4 kDa (115-329 aa)
包装
pkg of 5 μg
pkg of 50 μg
浓度
0.5 mg/mL
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
mouse ... CTSK(13038)
一般描述
Cathepsin K belongs to the peptidase C1 protein family and is a lysosomal cysteine protease. The associated gene is strongly expressed on osteoclasts and is also present in cardiomyocytes. Cathepsin K is the most abundant and main protease involved with osteoclastic activity.
生化/生理作用
Cathepsin K is responsible for collagenolytic and elastolytic activities. It can degrade type II collagen and thus participates in the degradation of articular cartilage. It also plays an important role in osteoarthritis and periodontitis. Removal of the cathepsin K activity provides protection against agents inducing metabolic stress in the heart. Absence of cathepsin K also protects from age-related decline in cardiac function by inhibition of caspase-associated and caspase-independent cell death.
外形
0.5 mg/mL solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0) with 50% glycerol.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Deficiency of cathepsin K prevents inflammation and bone erosion in rheumatoid arthritis and periodontitis and reveals its shared osteoimmune role.
Hao L, et al.
Febs Letters, 589, 1331-1331 (2015)
In vivo fluorescence reflectance imaging of protease activity in a mouse model of post-traumatic osteoarthritis.
Satkunananthan PB, et al.
Osteoarthritis and Cartilage, 22, 1461-1461 (2014)
Cathepsin K knockout alleviates aging-induced cardiac dysfunction.
Hua Y, et al.
Aging Cell, 14, 345-345 (2015)
Cathepsin K knockout alleviates pressure overload-induced cardiac hypertrophy.
Hua Y, et al.
Hypertension, 61, 1184-1184 (2013)
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