推荐产品
生物来源
mouse
重组
expressed in E. coli
方案
≥98% (SDS-PAGE)
表单
liquid
分子量
25.5 kDa
包装
pkg of 5 μg
pkg of 50 μg
pkg of 500 μg
浓度
0.25 mg/mL
杂质
≤1 EU/μg endotoxin (LAL test)
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
mouse ... TGF-beta-1(21803)
一般描述
TGFβ3 (transforming growth factor β3) is one of the three isoforms of mammalian TGFβ, and all the isoforms share high sequence similarity at the active domains, with TGFβ3 showing highest similarity with TGFβ1.
Recombinant mouse TGF-β3 is a non-glycosylated, disulfide-linked homodimer, containing two 112 amino acid chains, with a total molecular weight of 25.5kDa.
Recombinant mouse TGF-β3 is a non-glycosylated, disulfide-linked homodimer, containing two 112 amino acid chains, with a total molecular weight of 25.5kDa.
The TGFB1 gene is mapped to human chromosome 19q13.2. The encoded protein is an anti-inflammatory cytokine.
生化/生理作用
TGFβ3 (transforming growth factor β3) shows higher expression levels during late stage tumors, and hence, is thought to be associated with tumorigenesis. However, studies also show that in skin, breast, oral and gastric mucosa and other types of tissue, this protein confers protection against tumorigenesis. It plays crucial role in the development of systems such as heart, breast and lung. It is essential for mouse embryonic palate fusion, as inactivation results in non-fusion of palatal shelves. This protein plays a crucial role in orofacial development and is essential for excisional wound repair in vivo.
外形
0.25 mg/mL solution containing 20% ethanol and 0.12% acetic acid (AcOH) .
储存分类代码
3 - Flammable liquids
WGK
WGK 1
闪点(°F)
does not flash
闪点(°C)
does not flash
法规信息
新产品
从最新的版本中选择一种：
Transforming growth factor Beta 3 is required for excisional wound repair in vivo.
Le M et al
PLoS ONE, 7(10), e48040-e48040 (2012)
Peripheral regulatory T cells and anti-inflammatory cytokines in children with juvenile idiopathic arthritis
Sznurkowska K, et al.
Acta Biochimica Polonica, 65(1), 1908-1916 (2018)
TGF-beta3 and cancer: a review.
Laverty HG et al
Cytokine & Growth Factor Reviews, 20(4), 305-317 (2009)
Identification of PAK4 as a putative target gene for amplification within 19q13.12-q13.2 in oral squamous-cell carcinoma
Begum A, et al.
Cancer Science, 100(10), 1908-1916 (2009)
Zhaoyang Liu et al.
eLife, 10 (2021-07-29)
Adolescent idiopathic scoliosis (AIS) is the most common spine disorder affecting children worldwide, yet little is known about the pathogenesis of this disorder. Here, we demonstrate that genetic regulation of structural components of the axial skeleton, the intervertebral discs, and
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