SRP6542
FNDC5
recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
别名:
Fibronectin Type III Domain-containing Protein 5, Fibronectin Type III Repeat-containing Protein 2
产品名称
FNDC5, recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
recombinant
expressed in E. coli
assay
≥95% (SDS-PAGE)
form
lyophilized
mol wt
~160 kDa
packaging
pkg of 10 μg
impurities
<0.1 EU/μg endotoxin (LAL test)
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... FNDC5(252995)
General description
Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.
extracellular domain, human aa 32-152 / mouse aa 29-149 is untagged. FNDC5 extracellular domain has 100% identity between human, mouse and rat.
Physical form
Lyophilized in PBS.
Preparation Note
Reconstitute with 100 μsterile distilled water.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Guo-Hua Fan et al.
Cellular signalling, 72, 109665-109665 (2020-05-01)
Therapeutic benefits and clinical application of paclitaxel for treating non-small cell lung cancers (NSCLCs) are extremely hampered due to the chemoresistance. A recent study found that fibronectin type III domain-containing protein 5 (FNDC5) was downregulated in NSCLCs cells and negatively
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