推荐产品
生物来源
human
重组
expressed in E. coli
检测方案
≥90% (SDS-PAGE)
形式
liquid
分子量
~65 kDa (Human FTO aa 2-505 is fused at the N-terminus to a His-tag.)
包装
pkg of 10 μg
浓度
0.2 mg/mL
杂质
<1 EU/μg endotoxin (LAL test)
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... FTO(79068)
一般描述
FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse ‘fused toes′ mutation. An association between FTO genotype and type 2 diabetes has been confirmed. The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, triglycerides, and lower HDL-cholesterol.
The fat mass and obesity-associated (FTO) gene is mapped to human chromosome 16q12.2. The encoded protein is a nuclear protein and belongs to the AlkB-related non-haem iron- and 2-oxoglutarate-dependent dioxygenase family.
生化/生理作用
FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse ‘fused toes′ mutation. An association between FTO genotype and type 2 diabetes has been confirmed. The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, triglycerides, and lower high-density lipoprotein (HDL)-cholesterol. FTO stimulates adipogenesis, tumorigenesis, and drug resistance of cancer cells. It does so by reducing the levels of messenger RNA N6-methyladenosine (m6A) of certain genes post-transcription. The FTO single-nucleotide polymorphisms (SNPs) are associated with elevated body mass and obesity in humans.
外形
0.2 mg/mL of 0.2 μm-filtered solution in 55 mM Tris-Cl, pH 8.2 containing 150 mM NaCl.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Rachel M Freathy et al.
Diabetes, 57(5), 1419-1426 (2008-03-19)
Common variation in the FTO gene is associated with BMI and type 2 diabetes. Increased BMI is associated with diabetes risk factors, including raised insulin, glucose, and triglycerides. We aimed to test whether FTO genotype is associated with variation in
Xiaolan Deng et al.
Frontiers in endocrinology, 9, 396-396 (2018-08-15)
Fat mass and obesity-associated protein (FTO) single-nucleotide polymorphisms (SNPs) have been linked to increased body mass and obesity in humans by genome-wide association studies (GWAS) since 2007. Although some recent studies suggest that the obesity-related SNPs in FTO influence obesity
Katherine A Fawcett et al.
Trends in genetics : TIG, 26(6), 266-274 (2010-04-13)
In 2007, an association of single nucleotide polymorphisms (SNPs) in the fat mass and obesity-associated (FTO) gene region with body mass index (BMI) and risk of obesity was identified in multiple populations, making FTO the first locus unequivocally associated with
Eikan Mishima et al.
PloS one, 10(11), e0143756-e0143756 (2015-11-26)
The biological roles of RNA modifications are still largely not understood. Thus, developing a method for detecting RNA modifications is important for further clarification. We developed a method for detecting RNA modifications called immuno-northern blotting (INB) analysis and herein introduce
Ning Lan et al.
Frontiers in genetics, 11, 559138-559138 (2020-12-12)
In recent years, the prevalence of obesity and cancer have been rising. Since this poses a serious threat to human health, the relationship between the two has attracted much attention. This study examined whether fat mass and obesity-associated (FTO) genes
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