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主要文件

安全信息

SRP6474

Sigma-Aldrich

GFRA1/GDNFRA human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

别名:

GDNFR, GFR-ALPHA-1, RET1L, RETL1, TRNR1

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About This Item

UNSPSC代码:
12352200
NACRES:
NA.32

生物来源

human

重组

expressed in HEK 293 cells

标签

6-His tagged (C-terminus)

方案

≥95% (SDS-PAGE)

表单

lyophilized

分子量

calculated mol wt 45.5 kDa
observed mol wt 55-60 kDa (DTT-reduced. Asp 25 is the predicted N-terminal.)

包装

pkg of 10 and 50 μg

杂质

<1 EU/μg endotoxin (LAL test)

UniProt登记号

运输

wet ice

储存温度

−20°C

基因信息

human ... GFRA1(2674)

一般描述

GDNF family receptor α-1 (GFRA1) also known as RET ligand 1 (RETL1), TGF-β-related neurotrophic factor receptor 1 (TRNR1), is a novel glycosylphosphatidylinositol (GPI)-linked cell surface receptor, and belongs to the glial cell line-derived neurotrophic factor (GDNF) receptor subfamily. The GDNF family ligands comprises GDNF, Neurturin (NTN), Artemin, and Persephin. GDNF and NTN are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA1 mediates the association with and activation of the RET tyrosine kinase receptor (RTK), and subsequently initiates the RET signaling pathway. GFR α-mediated signaling plays an important role in the survival, differentiation, and migration of central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system, as well as the inflammatory response in some carcinomas.

外形

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

重悬

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

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