推荐产品
生物来源
human
重组
expressed in HEK 293 cells
标签
6-His tagged (C-terminus)
方案
≥95% (SDS-PAGE)
表单
lyophilized
分子量
calculated mol wt 35.8 kDa
observed mol wt 50-65 kDa (DTT-reduced. Protein migrates due to glycosylation. Asp 35 is the predicted N-terminal.)
包装
pkg of 10 μg
pkg of 50 μg
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... CD55(1604)
一般描述
CD55 (complement decay-accelerating factor), also known as DAF or decay accelerating factor, is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. CD55 /DAF is a 70 kDa membrane protein that regulates the complement system on the cell surface. This glycoprotein is broadly distributed among hematopoietic and non-hematopoietic cells.
生化/生理作用
CD55 (complement decay-accelerating factor) prevents the assembly of the C3bBb complex (the C3-convertase of the alternative pathway) or accelerates the disassembly of preformed convertase, thus blocking the formation of the membrane attack complex. It is a determinant for the Cromer blood group system. CD55 is known to bind CD97 via the first short consensus repeats (SCR). It also binds physiologically generated C3 convertases with its second and third SCRs. Binding results in an accelerated “decay”, or dissociation of active C3 convertases, thus blocking the development of C′ attack complexes on non-foreign cells. Finally, viruses and bacteria are also known to utilize multiple SCR sites for infection.
外形
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
重悬
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Molecular basis of reduced or absent expression of decay-accelerating factor in Cromer blood group phenotypes.
Lublin D M, et al.
Blood, 84(4), 1276-1282 (1994)
An understanding of intervertebral disc development, maturation and cell phenotype provides clues to direct cell-based tissue regeneration therapies for disc degeneration.
Rodrigues-Pinto R, et al.
European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 23(9), 1803-1814 (2014)
Structure of complement fragment C3b?factor H and implications for host protection by complement regulators.
Wu J, et al.
Nature Immunology, 10(7), 728-728 (2009)
Hantavirus causing hemorrhagic fever with renal syndrome enters from the apical surface and requires decay-accelerating factor (DAF/CD55).
Krautkramer E and Zeier M
Journal of Virology, 82(9), 4257-4264 (2008)
Membrane complement regulatory proteins.
Kim D D and Song W C
Clinical Immunology (Orlando, Fla.), 118(2-3), 127-136 (2006)
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