生物来源
human
重组
expressed in E. coli
检测方案
≥95% (SDS-PAGE)
形式
liquid
分子量
41.5 kDa (384 aa, 1-364 aa + His Tag)
包装
pkg of 100 μg
浓度
1 mg/mL
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... ALDOA(226)
一般描述
Aldolase A (ALDOA) is a ubiquitous glycolytic enzyme expressed in developing embryos and in adult muscles. The gene encoding it is localized on human chromosome 16p11.2. Recombinant human Aldolase A, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
生化/生理作用
In glycolysis, aldolase A (ALDOA) catalyzes the reversible reaction of fructose-1,6-bisphosphate to glyceraldehydes-3-phosphate and dihydroxyacetone phosphate. It is involved in a wide range of cellular functions such as maintenance of striated muscle contraction, cell shape and mobility, actin filament organization and ATP biosynthetic process. High expression level of ALDOA is reported in various forms of malignant cancers, including human lung squamous, renal cell and hepatocellular carcinomas. ALDOA deficiency causes myopathy and hemolytic anemia.
外形
1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 100 mM NaCl and 10% glycerol.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Comparative proteomics analysis of gastric cancer stem cells.
Morisaki T
PLoS ONE, 9(14) (2014)
Association and Mutation Analyses of 16p11.2 Autism Candidate Genes
Ravinesh A
PLoS ONE (2009)
Two cases of red cell aldolase deficiency associated with hereditary hemolytic anemia in a Japanese family.
Miwa S
American Journal of Hematology, 11(4) (1981)
Fructose-bisphosphate aldolase a is a potential metastasis-associated marker of lung squamous cell carcinoma and promotes lung cell tumorigenesis and migration.
Sha Du
PLoS ONE, 9(9) (2014)
Human aldolase A deficiency associated with a hemolytic anemia: thermolabile aldolase due to a single base mutation.
Kishi H
Proceedings of the National Academy of Sciences of the USA, 84(23) (1987)
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