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生物来源
human
重组
expressed in E. coli
方案
≥90% (SDS-PAGE)
表单
liquid
分子量
20 kDa (187 aa, 31-194 aa + His Tag)
包装
pkg of 100 μg
浓度
1 mg/mL
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... IL18BP(10068)
一般描述
IL18BP functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn′s disease. Recombinant human IL18BP protein, fused to His-tag at N-terminus, was expressed in E.coli.
外形
1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
历史批次信息供参考:
Ahmet Bal et al.
The Journal of surgical research, 201(1), 13-21 (2016-02-07)
The aim of this study was to investigate the possible protective effect of interleukin 18-binding protein (IL-18BP) on ischemia-reperfusion (I/R)-induced liver injury in experimental rat models. Liver is one of the most affected organs from I/R process. IL-18 is an
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