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生物来源
human plasma
检测方案
≥95% (SDS-PAGE)
形式
lyophilized
分子量
65 kDa
包装
pkg of 100 μg
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... KNG1(3827)
一般描述
KNG1 (kininogen 1) gene is localized to human chromosome 3, and codes for both high and low molecular weight kininogen. The high molecular weight kininogen (HK) is a 120kDa single chain glycoprotein.
LMW Kininogen is involved in blood pressure regulation since it is an endogenous protein substrate for tissue kallikrein. Proteolytic cleavage by kallikrein releases vasoactive bradykinin from LMW kininogen. In addition, LMW kininogen, like HMW kininogen, is a major extracellular cysteine protease inhibitor.
生化/生理作用
KNG1 (kininogen 1) exists in low and high molecular weight forms which are precursors for bradykinin and kallidin (Lys-Bradykinin), respectively. The high molecular weight kininogen (HK) functions as a cofactor for the stimulation of surface-bound Hageman factor (Factor XII) by kallikrein. HK is subsequently required for the activation of prekallikrein and Factor XI by the activated Hageman factor. These steps are essential for the initiation of coagulation, fibrinolysis, and the production of vasoactive peptides. Ile581Thr polymorphism in KNG1 gene is linked with increased susceptibility to venous thrombosis.
外形
Lyophilized from 10 mM Na acetate, pH 5.5 with 200 mM NaCI .
重悬
In water or aqueous buffer
警示用语：
Danger
危险分类
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
The shape of high molecular weight kininogen. Organization into structural domains, changes with activation, and interactions with prekallikrein, as determined by electron microscopy.
Weisel JW, et al.
The Journal of Biological Chemistry, 269(13), 10100-10106 (1994)
Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time.
Houlihan LM, et al.
American Journal of Human Genetics, 86(4), 626-631 (2010)
Genome-wide meta-analyses of plasma renin activity and concentration reveal association with the kininogen 1 and prekallikrein genes.
Lieb W, et al.
Circulation. Cardiovascular Genetics, 8(1), 131-140 (2015)
KNG1 Ile581Thr and susceptibility to venous thrombosis.
Morange PE, et al.
Blood, 117(13), 3692-3694 (2011)
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