SRP6319
Kininogen,LMW from human plasma
≥95% (SDS-PAGE)
别名:
Alpha-2-thiol proteinase inhibitor, BDK, Fitzgerald factor, High molecular weight Kininogen, KNG, Kininogen-1 heavy chain, Low molecular weight growth-promoting, Williams-Fitzgerald-Flaujeac factor
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关于此项目
UNSPSC Code:
12352200
Form:
lyophilized
Assay:
≥95% (SDS-PAGE)
Biological source:
human plasma
Mol wt:
65 kDa
biological source
human plasma
assay
≥95% (SDS-PAGE)
form
lyophilized
mol wt
65 kDa
packaging
pkg of 100 μg
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... KNG1(3827)
General description
KNG1 (kininogen 1) gene is localized to human chromosome 3, and codes for both high and low molecular weight kininogen. The high molecular weight kininogen (HK) is a 120kDa single chain glycoprotein.
LMW Kininogen is involved in blood pressure regulation since it is an endogenous protein substrate for tissue kallikrein. Proteolytic cleavage by kallikrein releases vasoactive bradykinin from LMW kininogen. In addition, LMW kininogen, like HMW kininogen, is a major extracellular cysteine protease inhibitor.
Biochem/physiol Actions
KNG1 (kininogen 1) exists in low and high molecular weight forms which are precursors for bradykinin and kallidin (Lys-Bradykinin), respectively. The high molecular weight kininogen (HK) functions as a cofactor for the stimulation of surface-bound Hageman factor (Factor XII) by kallikrein. HK is subsequently required for the activation of prekallikrein and Factor XI by the activated Hageman factor. These steps are essential for the initiation of coagulation, fibrinolysis, and the production of vasoactive peptides. Ile581Thr polymorphism in KNG1 gene is linked with increased susceptibility to venous thrombosis.
Physical form
Lyophilized from 10 mM Na acetate, pH 5.5 with 200 mM NaCI .
Preparation Note
In water or aqueous buffer
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time.
Houlihan LM, et al.
American Journal of Human Genetics, 86(4), 626-631 (2010)
The shape of high molecular weight kininogen. Organization into structural domains, changes with activation, and interactions with prekallikrein, as determined by electron microscopy.
Weisel JW, et al.
The Journal of Biological Chemistry, 269(13), 10100-10106 (1994)
Genome-wide meta-analyses of plasma renin activity and concentration reveal association with the kininogen 1 and prekallikrein genes.
Lieb W, et al.
Circulation. Cardiovascular Genetics, 8(1), 131-140 (2015)
KNG1 Ile581Thr and susceptibility to venous thrombosis.
Morange PE, et al.
Blood, 117(13), 3692-3694 (2011)
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