推荐产品
生物来源
human
重组
expressed in E. coli
方案
≥95% (SDS-PAGE)
表单
lyophilized powder
分子量
~13 kDa
包装
pkg of 10 μg
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... FNDC5(252995)
一般描述
鸢尾素是最近鉴定的由小鼠和人类骨骼肌分泌的运动诱导激素。鸢尾素是从I型膜蛋白FNDC5（纤连蛋白 III 型域包含蛋白 5）上切割出来的。 FNDC5主要表达于肌肉中。肾、肝和肺中也含有低水平的mRNA。 FNDC5基因位于人染色体1p35.1上。
生化/生理作用
鸢尾素（Irisin）能够激活米色脂肪细胞（米色细胞的基因表达模式与白色或棕色脂肪不同，并且对多肽激素鸢尾素更敏感），并通过增加能量消耗来改善全身代谢。它主要负责将白色脂肪转化为棕色脂肪。这种转化增强了代谢解偶联和热量消耗。 鸢尾素始终与运动对细胞代谢的有益反应有关。在肥胖和2型糖尿病患者中，低水平的循环鸢尾素是脂肪组织和肌肉的特征。
外形
从PBS中冻干。
重悬
使用100μL 无菌水重悬至 0.1 mg/mL。
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Rujun Zeng et al.
Bioscience trends, 12(6), 580-586 (2019-01-25)
Irisin is a myokine secreted from the cleavage of fibronectin type III domain-containing protein 5 (FNDC5) and has an effect on bone formation. There are limited studies about the structure of irisin and its functional unit. In order to clarify
Endre Kristóf et al.
Experimental cell research, 377(1-2), 47-55 (2019-02-23)
Brown and beige adipocytes contribute significantly to the regulation of whole body energy expenditure and systemic metabolic homeostasis not exclusively by thermogenesis through mitochondrial uncoupling. Several studies have provided evidence in rodents that brown and beige adipocytes produce a set
Elke Albrecht et al.
Molecular metabolism, 34, 124-135 (2020-03-18)
Considerable uncertainty remains regarding the veracity of measuring myokine irisin more than seven years after its original description. Unresolved issues include the nature of transcription of the irisin precursor fibronectin type III domain containing 5 (FNDC5) gene across species, the
Is irisin a human exercise gene?
Timmons JA
Nature, 488, E9-10 (2012)
Feng-Sheng Wang et al.
Antioxidants (Basel, Switzerland), 9(9) (2020-09-05)
Compromised autophagy and mitochondrial dysfunction downregulate chondrocytic activity, accelerating the development of osteoarthritis (OA). Irisin, a cleaved form of fibronectin type III domain containing 5 (FNDC5), regulates bone turnover and muscle homeostasis. Little is known about the effect of Irisin
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