SRP6172
IL-4 人
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
别名:
B 细胞刺激因子 1 (BSF-1), BCGF, Binetrakin, Pitrakinra, 淋巴细胞刺激因子 1
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关于此项目
NACRES:
NA.32
UNSPSC Code:
12352202
Form:
lyophilized
Assay:
≥95% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in HEK 293 cells
Mol wt:
(14 and 19 kDa, monomer)
biological source
human
recombinant
expressed in HEK 293 cells
assay
≥95% (SDS-PAGE)
form
lyophilized
mol wt
(14 and 19 kDa, monomer)
packaging
pkg of 10 μg
technique(s)
cell culture | mammalian: suitable
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... IL4(3565)
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General description
白细胞介素 4（IL-4） 是一种多效细胞因子和有效的淋巴样细胞生长因子。它由活化的 T 细胞产生，是白细胞介素 4 受体的配体。编码这种蛋白的基因位于人类染色体 5q31.1 上。已有研究报道了编码不同同种型的该基因的 2 个选择性剪接转录变体。
Biochem/physiol Actions
白细胞介素 4（IL-4） 刺激某些 B 细胞和 T 细胞的生长和存活。白细胞介素 4 受体还与白细胞介素 13（IL-13） 结合，这可能有助于这种细胞因子和 IL-13 的许多重叠功能。STAT6（信号转导和转录激活因子 6）已被证明在介导这种细胞因子的免疫调节信号中起核心作用。该蛋白质表现出抗炎反应，并通过防止细胞内病原体在免疫过程中发挥作用。
Physical form
从 20 mM Tris-HCl，pH 7.4 和 300 mM NaCl 溶液中冻干。
Preparation Note
打开样品瓶之前需离心。
用含0.1%无内毒素重组人血清白蛋白的无菌PBS复溶。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Interleukin 4 mediates autocrine growth of helper T cells after antigenic stimulation.
Fernandez-Botran R
Proceedings of the National Academy of Sciences of the USA, 83(24), 9689-9693 (1986)
D G Marsh et al.
Science (New York, N.Y.), 264(5162), 1152-1156 (1994-05-20)
Sib-pair analysis of 170 individuals from 11 Amish families revealed evidence for linkage of five markers in chromosome 5q31.1 with a gene controlling total serum immunoglobulin E (IgE) concentration. No linkage was found between these markers and specific IgE antibody
Interleukin 4 inhibition as a potential therapeutic in pemphigus.
Tavakolpour S and Tavakolpour V
Cytokine, 77, 189-195 (2016)
Lancelot Marique et al.
The Journal of clinical endocrinology and metabolism, 99(5), 1722-1732 (2014-01-31)
Hashimoto's thyroiditis (HT) and Graves' disease (GD) are thyroid autoimmune disorders driven by Th1 and Th2 immune responses, respectively. Caveolin-1 (Cav-1), thyroid peroxidase (TPO), and dual oxidase (DUOX) are thought to be part of the thyroxisome, which is essential to
Masanori Kobayashi et al.
Cancer immunology, immunotherapy : CII, 63(8), 797-806 (2014-04-30)
Dendritic cell (DC)-based cancer vaccines may have a significant benefit to patients with advanced pancreatic cancer. However, variations among clinical studies make it difficult to compare clinical outcomes. Here, we identified factors that determined the clinical benefits by analyzing data
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