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生物来源
human
重组
expressed in human cells
方案
≥95% (SDS-PAGE)
表单
lyophilized
分子量
(17 and 27 kDa, monomer, glycosylated)
包装
pkg of 10 μg
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... FGF4(2249)
一般描述
The FGF4 (fibroblast growth factor 4) gene is mapped to human chromosome 11q13.3. It is expressed during early embryonic development. In adults, it is strongly expressed in the testis.
生化/生理作用
FGF4 (fibroblast growth factor 4) helps in preserving the self-renewal capability of normal stem cells. The encoded protein has the ability to interact with FGFR1c (FGF receptor 1c) and FGFR2c. It also binds to FGFR3c and FGFR4, but to a lesser extent. FGFR4 is also required for cellular differentiation, morphogenesis and proliferation. It modulates proliferation and differentiation of normal stem cells, progenitor cells and cancer cells.
外形
Lyophilized from a PBS solution.
制备说明
Centrifuge the vial prior to opening.
重悬
Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity.
Yasuda K, et al.
Laboratory Investigation; a Journal of Technical Methods and Pathology, 94(12), 1355-1355 (2014)
Eryn Wicklow et al.
PLoS genetics, 10(10), e1004618-e1004618 (2014-10-24)
Pluripotent epiblast (EPI) cells, present in the inner cell mass (ICM) of the mouse blastocyst, are progenitors of both embryonic stem (ES) cells and the fetus. Discovering how pluripotency genes regulate cell fate decisions in the blastocyst provides a valuable
Martina Johannesson et al.
PloS one, 4(3), e4794-e4794 (2009-03-12)
Retinoic acid (RA) and fibroblast growth factor 4 (FGF4) signaling control endoderm patterning and pancreas induction/expansion. Based on these findings, RA and FGFs, excluding FGF4, have frequently been used in differentiation protocols to direct differentiation of hESCs into endodermal and
Increased FGF3 and FGF4 gene dosage is a risk factor for craniosynostosis.
Grillo L, et al.
Gene, 534(2), 435-439 (2014)
Evgeniya A Vaskova et al.
PloS one, 9(2), e88256-e88256 (2014-02-08)
In rodent female mammals, there are two forms of X-inactivation - imprinted and random which take place in extraembryonic and embryonic tissues, respectively. The inactive X-chromosome during random X-inactivation was shown to contain two types of facultative heterochromatin that alternate
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Fibroblast growth factors in cell culture and various growth factors for your research
用于细胞培养的成纤维细胞生长因子，以及用于您的研究的各类生长因子
Role of growth factors in stem cell differentiation and various growth factors for your research at sigmaaldrich.com
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