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一般描述
BMP4 (bone morphogenetic protein 4), a member of the highly conserved BMP family, is a growth factor and a pro-inflammatory and pro-atherogenic cytokine. BMPs are part of the TGFβ (tumor growth factor) superfamily of proteins. BMP4 gene is localized to human chromosome 14q22-q23.
生化/生理作用
BMP4 (bone morphogenetic protein 4) is involved in modulating cell development in a wide variety of cells. It promotes the proliferation and migration of hepatocellular carcinoma cells, and the multiplication of ALK3 (activin-like kinase)-positive cells in skeletal muscle. This protein prevents the proliferation of lung fibroblasts and induces their differentiation into myocytes. In Sertoli cells, it promotes DNA synthesis and hence, the proliferation of Sertoli cells through Smad1/5 (small mothers against decapentaplegic) and ID2/3 (DNA binding protein inhibitor) pathway, and aberration in BMP4 expression results in azoospermia. In human males, the serum levels of BMP4 is linked with coronary artery disease (CAD) severity. BMP4 is crucial for maintaining the self-renewal capacity of ES (embryonic stem) cells, and achieves so by inhibiting extracellular receptor kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) pathways.
外形
Lyophilized from a PBS solution.
制备说明
Centrifuge the vial prior to opening.
重悬
Reconstitute in sterile 4 mM HCl containing 0.1% endotoxin-free recombinant human serum albumin.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
BMP4 promotes human Sertoli cell proliferation via Smad1/5 and ID2/3 pathway and its abnormality is associated with azoospermia.
Hai Y et al
Discovery Medicine, 19(105), 311-325 (2015)
BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways.
Qi X et al
Proceedings of the National Academy of Sciences of the USA, 101(16), 6027-6032 (2004)
Serum Bone Morphogenic Protein-4 Contributes to Discriminating Coronary Artery Disease Severity.
Park CS et al
Medicine, 94(3), e1530-e1530 (2015)
Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis.
Weaver M et al
Development, 127(12), 2695-2704 (2000)
Bmp4 is required for the generation of primordial germ cells in the mouse embryo.
Lawson KA et al
Genes & Development, 13(4), 424-436 (1999)
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