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安全信息

SRP6119

Sigma-Aldrich

DHFR from mouse

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

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别名:
DYR, Dihydrofolate reductase, N/A
UNSPSC代码:
12352204
NACRES:
NA.32

生物来源

mouse

重组

expressed in E. coli

检测方案

≥95% (SDS-PAGE)

形式

liquid

分子量

23.8 kDa (207 aa, 1-187 aa + NT His-Tag)

包装

pkg of 100 μg

NCBI登记号

UniProt登记号

运输

dry ice

储存温度

−70°C

基因信息

mouse ... DHFR(13361)

一般描述

Dihydrofolate reductase (DHFR) is a member of the reductase family of enzymes that is ubiquitously expressed in all organisms. The gene encoding this protein is localized on mouse chromosome 13.

生化/生理作用

DHFR catalyzes the nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of dihydrofolate to tetrahydrofolate, and it is essential for the synthesis of thymidylate, purines and several amino acids. Expression of methotrexate (MTX)-resistant variants of DHFR in normal hematopoietic cells is a potential strategy to permit administration of larger doses of MTX by alleviating drug toxicity in normal cells and tissues that are drug sensitive.

外形

1 mg/mL solution in 20 mM Tris-HCl buffer (pH 8.0) containing 0.1 M NaCl, 2 mM DTT and 10% glycerol.

制备说明

Centrifuge the vial prior to opening.

其他说明

MGSSHHHHHH SSGLVPRGSH MVRPLNCIVA VSQNMGIGKN GDLPWPPLRN EFKYFQRMTT TSSVEGKQNL VIMGRKTWFS IPEKNRPLKD RINIVLSREL KEPPRGAHFL AKSLDDALRL IEQPELASKV DMVWIVGGSS VYQEAMNQPG HLRLFVTRIM QEFESDTFFP EIDLGKYKLL PEYPGVLSEV QEEKGIKYKF EVYEKKD

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Dihydrofolate reductase gene variations in susceptibility to disease and treatment outcomes.
Askari BS and Krajinovic M
Current Genomics, 11(8), 578-583 (2010)
A molecular genetic linkage map of mouse chromosome 13 anchored by the beige (bg) and satin (sa) loci.
Justice MJ
Genomics, 6(2), 341-351 (1990)
M N Lombardo et al.
Drug metabolism and disposition: the biological fate of chemicals, 47(9), 995-1003 (2019-06-16)
Pharmacokinetic/pharmacodynamic properties are strongly correlated with the in vivo efficacy of antibiotics. Propargyl-linked antifolates, a novel class of antibiotics, demonstrate potent antibacterial activity against both Gram-positive and Gram-negative pathogenic bacteria, including multidrug-resistant Staphylococcus aureus Here, we report our efforts to

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