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生物来源
mouse
重组
expressed in E. coli
检测方案
≥95% (HPLC)
≥95% (SDS-PAGE)
形式
lyophilized
分子量
26.2 kDa
包装
pkg of 10 μg
技术
cell culture | embryo: suitable
NCBI登记号
运输
wet ice
储存温度
−20°C
基因信息
mouse ... INHBA(3624)
一般描述
Activin A is a member of the TGF (transforming growth factor)-β family of proteins produced by many cell types throughout development. Mouse Activin A has 100% amino acid sequence identity to human, rat, porcine, bovine and feline proteins. Recombinant mouse Activin A is a nonglycosylated homodimer, containing two 117 amino acid chains, with a total molecular weight of 26.2 kDa.
应用
Activin A has been used:
- to induce differentiation of embryonic stem cells to pancreatic β cells
- in the induction of bone marrow-derived mesenchymal stem cells to insulin-producing cells
- to induce endoderm differentiation from human embryonic stem cells
- as a component of β cell induction medium.
生化/生理作用
Activins interact with Type I and Type II serine/threonine kinases to signal to SMAD proteins to regulate a variety of functions, including cell proliferation, differentiation, wound healing, apoptosis, metabolism, etc. Activin A is a homodimer of two β A chains and is not biologically active until the N terminal propeptide is cleaved from each chain. Activin A is involved in mesoderm formation and hematopoietic development.
外形
Recombinant mouse Activin A is lyophilized with 0.02% TFA.
制备说明
Centrifuge the vial prior to opening.
重悬
Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water, which can then be further diluted to other aqueous solutions.
其他说明
MGLECDGKVN ICCKKQFFVS FKDIGWNDWI IAPSGYHANY CEGECPSHIA GTSGSSLSFH STVINHYRMR GHSPFANLKS CCVPTKLRPM SMLYYDDGQN IIKKDIQNMI VEECGCS
警示用语:
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Requirement for activin A and transforming growth factor--beta 1 pro-regions in homodimer assembly.
Science, 247, 1328-1330 (1990)
Differentiation of bone marrow-derived mesenchymal stem cells from diabetic patients into insulin-producing cells in vitro.
Chinese Medical Journal (English Edition), 120, 771-776 (2007)
In vitro derivation of functional insulin-producing cells from human embryonic stem cells.
Cell Research, 17, 333-344 (2007)
Functional analysis of activins during mammalian development.
Nature, 374, 354-356 (1995)
Different phenotypes for mice deficient in either activins or activin receptor type II.
Nature, 374, 356-360 (1995)
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