推荐产品
生物来源
human
重组
expressed in E. coli
方案
≥95% (HPLC)
表单
liquid
分子量
8.5 kDa
包装
pkg of 50 μg
技术
protein purification: suitable
杂质
Endotoxin, tested
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... UBA2(7311)
一般描述
Ubiquitin Aldehyde was first synthesized by the reduction by borohydride of ubiquitin thioester, produced by the dehydration of the binary-ubiquitin-UCH-L3 (ubiquitin C-terminal hydrolase L3) complex.
应用
Ubiquitin Aldehyde human has been added to protein homogenates during the purification of ubiquitinated proteins.
生化/生理作用
Ubiquitin Aldehyde is a synthetic inhibitor of isopeptidases, proteins that hydrolyze the bond between Ub (ubiquitin) polypeptide and its protein adduct. In β-thalassemia, anemia results due to insufficiency in hemoglobin (Hb) β-subunit synthesis which leads to excess amounts of Hbα subunits, resulting in erythroid cell hemolysis. Studies show that ubiquitin aldehyde increases the proteolysis of Hbα subunits, therefore, preventing hemolysis. Hence, this might have potential as a therapeutic approach to treatment of β-thalassemia.
外形
An aqueous solution containing 0.15 M HCl
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Ubiquitin and the Biology of the Cell
Peters JM et al
Springer Science & Business Media (2013)
J R Shaeffer et al.
Blood, 90(3), 1300-1308 (1997-08-01)
Two major causes of the anemia in beta-thalassemia are a deficiency in hemoglobin (Hb) beta-subunit (and consequently HbA) synthesis and, due to the resulting excess of Hb alpha-subunits, erythroid cell hemolysis. The hemolytic component might be ameliorated by increasing the
Hu-Hui Chen et al.
Molecular plant, 11(5), 706-719 (2018-03-06)
Unveiling the signal transduction of phytohormone abscisic acid (ABA) and its regulatory mechanisms is critical for developing the strategies toward improving plant responses to stressful environments. ABA signaling is perceived and mediated by multiple PYR/PYL receptors, whose post-translational modifications, especially
Lingyao Kong et al.
Nature communications, 6, 8630-8630 (2015-10-21)
Clade A protein phosphatase 2Cs (PP2Cs) are abscisic acid (ABA) co-receptors that block ABA signalling by inhibiting the downstream protein kinases. ABA signalling is activated after PP2Cs are inhibited by ABA-bound PYR/PYL/RCAR ABA receptors (PYLs) in Arabidopsis. However, whether these
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