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生物来源
human
重组
expressed in E. coli
方案
≥98% (HPLC)
≥98% (SDS-PAGE)
表单
lyophilized
分子量
16.0 kDa
包装
pkg of 25 μg
杂质
Endotoxin, tested
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... RARRES2(5919)
一般描述
Chemerin, which is also known as retinoic acid receptor responder 2 (RARRES2), is a chemoattractant expressed in white adipose, liver and lung tissues. It is an immunomodulating factor. The protein is a ligand for the G-protein coupled receptor known as ChemR23 (or chemokine-like receptor-1), which is expressed mainly on dendritic cells, macrophages and some adipocytes. The gene encoding it is localized on human chromosome 7q36.1. Recombinant human Chemerin, produced in Escherichia.coli, is a non-glycosylated protein containing 138 amino acids and having a total molecular mass of 16kDa.
生化/生理作用
Chemerin activates chemerin-like receptor 1 (CMKLR1) and stimulates chemotaxis in macrophages, natural killer cells and immature dendritic cells. It is also involved in the activation of extracellular signal-regulated kinases, stimulation of blood vessel formation, migration and invasion.
外形
Lyophilized from 0.2% TFA.
重悬
Centrifuge the vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile H?O to a concentration of 0.1mg/ml, which can be further diluted into other aqueous solutions.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
Association of Polymorphisms in STRA6 and RARRES2 Genes with Type 2 Diabetes in Southern Han Chinese.
Huang HW
BioMed Research International, 2016, 6589793-6589793 (2016)
Rui-Li Zhang et al.
Journal of cellular biochemistry, 120(12), 19621-19634 (2019-07-20)
Chemerin, a chemoattractant protein, is involved in endothelial dysfunction and vascular inflammation in pathological conditions. In a recent study, we observed the upregulation of chemerin in endothelial cells following in vitro treatment with Treponema pallidum. Here, we investigated the role
Jun-xian Zhou et al.
Acta pharmacologica Sinica, 35(5), 653-663 (2014-03-25)
The chemerin receptor CMKLR1 is one type of G protein-coupled receptors abundant in monocyte-derived dendritic cells and macrophages, which plays a key role in the entry of a subset of immunodeficiency viruses including HIV/SIV into lymphocytes and macrophages. The aim
Urszula Godlewska et al.
Frontiers in microbiology, 11, 1819-1819 (2020-08-28)
Chronic inflammatory skin diseases like psoriasis alter the local skin microbiome and lead to complications such as persistent infection with opportunistic/pathogenic bacteria. Disease-associated changes in microbiota may be due to downregulation of epidermal antimicrobial proteins/peptides, such as antimicrobial protein chemerin.
Valérie Wittamer et al.
The Journal of experimental medicine, 198(7), 977-985 (2003-10-08)
Dendritic cells (DCs) and macrophages are professional antigen-presenting cells (APCs) that play key roles in both innate and adaptive immunity. ChemR23 is an orphan G protein-coupled receptor related to chemokine receptors, which is expressed specifically in these cell types. Here
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