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一般描述
BCL2 gene encodes an integral inner mitochondrial membrane protein that acts as an antiapoptotic protein. The protein BAD can antagonize both the cell cycle and antiapoptotic functions of BCL2 through binding to the BH3 domain. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. BCL2 is phosphorylated on specific serine/threonine residues within the unstructured loop in response to diverse stimuli and such phosphorylation has been associated with the loss of the biological function of BCL2.
It is a target gene of nuclear factor κB (NF-κB). The gene encoding this protein is localized on human chromosome 18q21. B-cell lymphoma 2 (BCL-2) inhibits apoptosis in cells and has been shown to be upregulated in adenomas.
外形
Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
制备说明
After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
BCL2 protein expression in follicular lymphomas with t(14;18) chromosomal translocations.
Masir N
British Journal of Haematology, 144(5), 716-725 (2009)
BCL2 family in DNA damage and cell cycle control.
Zingkel S
Cell Death and Differentiation, 13(8), 1351-1359 (2006)
Posttranslational modifications of Bcl2 family members--a potential therapeutic target for human malignancy.
Basu A
Frontiers in Bioscience, 11, 1508-1521 (2006)
P. Riederer, D.B. Calne
Advances in Research on Neurodegeneration null
Bcl-2 localized at the nuclear compartment induces apoptosis after transient overexpression.
Portier BP and Taglialatela G
The Journal of Biological Chemistry, 281(52), 40493-40502 (2006)
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