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安全信息

SRP5251

Sigma-Aldrich

PKC-α，活性，GST 标记 from Xanopus sp.

PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

别名:

MGC82897, PRKCA

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About This Item

UNSPSC代码:
12352200
NACRES:
NA.32

生物来源

Xenopus sp.

重组

expressed in baculovirus infected Sf9 cells

产品线

PRECISIO®

方案

≥70% (SDS-PAGE)

表单

buffered aqueous glycerol solution

比活

186-290 nmol/min·mg

分子量

~103 kDa

NCBI登记号

BC078065

应用

cell analysis

运输

dry ice

储存温度

−70°C

基因信息

Xenopus laevis ... prkca(447031)

一般描述

Protein kinase C-α (PKC-α) is a member of the PKC family of serine- and threonine-specific protein kinases that can be activated by calcium and the secondary messenger diacylglycerol. The protein is expressed in the dorsal ectoderm of Xenopus.

生化/生理作用

Protein kinase C-α (PKC-α) has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint and cell volume control. It has been identified as a fundamental regulator of cardiac contractility and Ca2+ handling in myocytes.

外形

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

制备说明

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

法律信息

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
N258-3

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Protein kinase C isozymes have distinct roles in neural induction and competence in Xenopus.
Otte AP and Moon RT
Cell, 68(6), 1021-1029 (1992)
PKC-alpha regulates cardiac contractility and propensity toward heart failure.
Braz JC
Nature Medicine, 10(3), 248-254 (2004)
aPKC phosphorylates p27Xic1, providing a mechanistic link between apicobasal polarity and cell-cycle control.
Sabherwal N
Developmental Cell, 31(5), 559-571 (2014)
Yi Liu et al.
The Biochemical journal, 478(10), 1999-2017 (2021-05-08)
Human hepatic tryptophan 2,3-dioxygenase (hTDO) is a homotetrameric hemoprotein. It is one of the most rapidly degraded liver proteins with a half-life (t1/2) of ∼2.3 h, relative to an average t1/2 of ∼2-3 days for total liver protein. The molecular mechanism

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