SRP5251
PKC-α，活性，GST 标记 from Xanopus sp.
PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
别名:
MGC82897, PRKCA
产品名称
PKC-α，活性，GST 标记 from Xanopus sp., PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
biological source
Xenopus sp.
recombinant
expressed in baculovirus infected Sf9 cells
product line
PRECISIO®
assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
186-290 nmol/min·mg
mol wt
~103 kDa
NCBI accession no.
application(s)
cell analysis
shipped in
dry ice
storage temp.
−70°C
Gene Information
Xenopus laevis ... prkca(447031)
Biochem/physiol Actions
Protein kinase C-α (PKC-α) has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint and cell volume control. It has been identified as a fundamental regulator of cardiac contractility and Ca2+ handling in myocytes.
General description
Protein kinase C-α (PKC-α) is a member of the PKC family of serine- and threonine-specific protein kinases that can be activated by calcium and the secondary messenger diacylglycerol. The protein is expressed in the dorsal ectoderm of Xenopus.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Preparation Note
After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
PKC-alpha regulates cardiac contractility and propensity toward heart failure.
Braz JC
Nature Medicine, 10(3), 248-254 (2004)
Protein kinase C isozymes have distinct roles in neural induction and competence in Xenopus.
Otte AP and Moon RT
Cell, 68(6), 1021-1029 (1992)
aPKC phosphorylates p27Xic1, providing a mechanistic link between apicobasal polarity and cell-cycle control.
Sabherwal N
Developmental Cell, 31(5), 559-571 (2014)
Yi Liu et al.
The Biochemical journal, 478(10), 1999-2017 (2021-05-08)
Human hepatic tryptophan 2,3-dioxygenase (hTDO) is a homotetrameric hemoprotein. It is one of the most rapidly degraded liver proteins with a half-life (t1/2) of ∼2.3 h, relative to an average t1/2 of ∼2-3 days for total liver protein. The molecular mechanism
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