重组
expressed in baculovirus infected Sf9 cells
检测方案
≥70% (SDS-PAGE)
形式
buffered aqueous glycerol solution
分子量
~100 kDa
NCBI登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... PADI6(353238)
一般描述
Peptidyl arginine deiminase 6 (PAD6) or PADI6 is a member of the peptidylarginine deiminases. It is expressed in oocytes and preimplantation embryos. The gene encoding this protein is localized on human chromosome 1p36.
生化/生理作用
Peptidyl arginine deiminases (PADs) convert arginine residues to citrulline residues in the presence of calcium ions. The PAD family members are thought to be involved in multiple sclerosis and rheumatoid arthritis pathophysiology, and they play a role in epidermis homeostasis. PAD6 is essential for formation of a novel oocyte-restricted fibrous structure, the cytoplasmic lattices (CPLs). PAD6/CPL superstructure plays a key role in regulating microtubule-mediated organelle positioning and movement.
外形
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
制备说明
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
分析说明
This protein is not assayed for enzymatic activity.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Acefylline activates filaggrin deimination by peptidylarginine deiminases in the upper epidermis.
Mechin MC
Journal of Dermatological Science (2016)
Erik R Vossenaar et al.
BioEssays : news and reviews in molecular, cellular and developmental biology, 25(11), 1106-1118 (2003-10-28)
Peptidylarginine deiminase (PAD, EC 3.5.3.15) enzymes catalyze the conversion of protein-bound arginine to citrulline. This post-translational modification may have a big impact on the structure and function of the target protein. In this review, we will discuss the effects of
Regulation of mouse oocyte microtubule and organelle dynamics by PADI6 and the cytoplasmic lattices.
Rui Kan et al.
Developmental biology, 350(2), 311-322 (2010-12-15)
Organelle positioning and movement in oocytes is largely mediated by microtubules (MTs) and their associated motor proteins. While yet to be studied in germ cells, cargo trafficking in somatic cells is also facilitated by specific recognition of acetylated MTs by
Potential Role of Peptidylarginine Deiminase Enzymes and Protein Citrullination in Cancer Pathogenesis
Sunish Mohanan
Biochemistry Research International (2012)
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