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生物来源
human
重组
expressed in baculovirus infected Sf9 cells
检测方案
≥70% (SDS-PAGE)
形式
buffered aqueous glycerol solution
分子量
~95 kDa
NCBI登记号
应用
cell analysis
运输
dry ice
储存温度
−70°C
基因信息
human ... PADI1(29943)
一般描述
Peptidyl arginine deiminase 1 (PAD1) is a member of the peptidyl arginine deiminase family of enzymes. It is a component of the 26S proteasome, a multiprotein complex that degrades proteins targeted for destruction by the ubiquitin pathway. PAD1 is expressed in the epidermis and uterus. The gene encoding this protein is localized on human chromosome 1p36.13.
生化/生理作用
Peptidyl arginine deiminases catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The overexpression of PAD1 induced a distinctive pattern of multidrug resistance in mammalian cells and moderate resistance to ultraviolet light. PAD1 is also responsible for substrate deubiquitination during proteasomal degradation. It deiminates filaggrin in the last stages of keratinocyte differentiation. Thus, PAD1 has a role in epidermis function and homeostasis. The protein has been genetically associated with rheumatoid arthritis.
外形
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
制备说明
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
分析说明
This protein is not assayed for enzymatic activity.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Identification of 45 novel SNPs in the 83-kb region containing peptidylarginine deiminase types 1 and 3 loci on chromosomal band 1p36.13.
Lida A and Nakamura Y
Journal of Human Genetics (2004)
The peptidylarginine deiminases expressed in human epidermis differ in their substrate specificities and subcellular locations.
Mechin MC
Cellular and Molecular Life Sciences (2005)
Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation.
Proost P
The Journal of Experimental Medicine (2008)
Potential Role of Peptidylarginine Deiminase Enzymes and Protein Citrullination in Cancer Pathogenesis
Sunish Mohanan, et.la
Biochemistry Research International (2012)
Tingting Yao et al.
Nature, 419(6905), 403-407 (2002-09-28)
The 26S proteasome is responsible for most intracellular proteolysis in eukaryotes. Efficient substrate recognition relies on conjugation of substrates with multiple ubiquitin molecules and recognition of the polyubiquitin moiety by the 19S regulatory complex--a multisubunit assembly that is bound to
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