重组
expressed in baculovirus infected Sf9 cells
产品线
PRECISIO® Kinase
检测方案
≥70% (SDS-PAGE)
形式
buffered aqueous glycerol solution
比活
11.9-16.1 nmol/min·mg
分子量
~132 kDa
NCBI登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... EIF2AK4(440275)
一般描述
Eukaryotic translation initiation factor 2-α kinase 4 (EIF2AK4), also known as GCN2 is an enzyme encoded by EIF2AK4 gene in humans. In mouse, EIF2AK4 is widely expressed with prominent expression in liver and brain.
生化/生理作用
Eukaryotic translation initiation factor 2-α kinase 4 (EIF2AK4) is responsible for phosphorylation of the a subunit of the eukaryotic initiation factor 2 (eIF2α). The EIF2AK4 eIF2-α kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. The protein p58IPK inhibits EIF2AK4 activity. EIF2AK4 is linked to pulmonary veno-occlusive disease (PVOD) development and its pathway is associated with diseases such as cancer and Alzheimer′s disease. The protein affects many aspects of cellular physiology in response to a number of stresses such as starvation. Mutation in EIF2AK4 may cause autosomal-recessive pulmonary capillary hemangiomatosis (PCH). EIF2AK4 causes tumor growth and angiogenesis by expression of vascular endothelial growth factor (VEGF).
外形
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
制备说明
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
法律信息
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
p58IPK is an inhibitor of the eIF2a kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity.
Anne Roobol
The Biochemical Society, 465 (2014)
mino acid deprivation promotes tumor angiogenesis through the GCN2/ATF4 pathway
Yugang Wang
Neoplasia (2013)
EIF2AK4 mutations cause pulmonary veno-occlusive disease, a recessive form of pulmonary hypertension
Melanie Eyries
Nature Genetics, 46(46) (2013)
GCN2, an old dog with new tricks
Beata Grallert and Erik Boye
Biochemical Society Transactions, 41 (2013)
Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase
J J Berlanga
European Journal of Biochemistry (2014)
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