重组
expressed in E. coli
检测方案
≥70% (SDS-PAGE)
形式
buffered aqueous glycerol solution
分子量
~42 kDa
NCBI登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... CDKN2C(1031)
一般描述
p18INK4C is a member of the INK4 family of proteins that regulate the G1 to S cell cycle transition by binding to and inhibiting the pRb kinase activity of cyclin-dependent kinases 4 and 6. Mutation of p18INK4C impairs B-cell terminal differentiation and confers increased susceptibility to tumor development. p18INK4C can function as a tumor suppressor gene in Hodgkins lymphoma and its inactivation may contribute to the cell cycle deregulation and defective terminal differentiation characteristic of the Reed-Sternberg cells.
外形
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
制备说明
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Ravichandran N Venkataramani et al.
The Journal of biological chemistry, 277(50), 48827-48833 (2002-10-09)
p18(INK4c) is a member of the INK4 family of proteins that regulate the G(1) to S cell cycle transition by binding to and inhibiting the pRb kinase activity of cyclin-dependent kinases 4 and 6. The p16(INK4a) member of the INK4
Abel Sánchez-Aguilera et al.
Blood, 103(6), 2351-2357 (2003-12-03)
p18INK4c is a cyclin-dependent kinase (CDK) inhibitor that interferes with the Rb-kinase activity of CDK6/CDK4. Disruption of p18INK4c in mice impairs B-cell terminal differentiation and confers increased susceptibility to tumor development; however, alterations of p18INK4c in human tumors have rarely
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