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重组
expressed in baculovirus infected Sf9 cells
产品线
PRECISIO® Kinase
方案
≥70% (SDS-PAGE)
表单
buffered aqueous glycerol solution
比活
46-62 nmol/min·mg
分子量
~125 kDa
NCBI登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... ULK1(8408)
一般描述
Unc-51 like autophagy activating kinase 1 (ULK1) is a serine/threonine protein kinase which forms a component of the ULK1 protein kinase complex. This protein complex also contains the adaptor proteins ATG (autophagy-related) 13, RB1CC1/FIP200 (RB1-inducible coiled-coil 1), and ATG101. The gene encoding this protein is localized on human chromosome 12q24.33.
应用
GST-ULK1 has been used in in vitro kinase assay.
生化/生理作用
Unc-51 like autophagy activating kinase 1 (ULK1) protein kinase plays a crucial role in the control of autophagy initiation. This protein is responsible for activating a cascade of signaling pathways which results in the formation of phagosomes. ULK1 is also required for the control of the expression of key interferon-stimulated genes (ISGs).
外形
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
制备说明
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
法律信息
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Computational analysis of an autophagy/translation switch based on mutual inhibition of MTORC1 and ULK1.
Szymanska Pp
PLoS ONE (2015)
Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy
Stefan D
Autophagy (2015)
Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy.
Driebren S
Autophagy (2015)
Missense Mutation in Pseudouridine Synthase 1 (PUS1) Causes Mitochondrial Myopathy and Sideroblastic Anemia (MLASA)
YelenaBykhovskaya
The American Journal on Addictions (2004)
Central role of ULK1 in type I interferon signaling.
Saleiro D
Cell Reports (2015)
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