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Merck
CN
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安全信息

SRP5096

Sigma-Aldrich

ULK1 (1-649)，活性，GST 标记 人

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

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别名:
ATG1, FLJ38455, UNC51, Unc51.1
UNSPSC代码:
12352200
NACRES:
NA.32

重组

expressed in baculovirus infected Sf9 cells

产品线

PRECISIO® Kinase

检测方案

≥70% (SDS-PAGE)

形式

buffered aqueous glycerol solution

比活

46-62 nmol/min·mg

分子量

~125 kDa

NCBI登记号

BC111603

运输

dry ice

储存温度

−70°C

基因信息

human ... ULK1(8408)

一般描述

Unc-51 like autophagy activating kinase 1 (ULK1) is a serine/threonine protein kinase which forms a component of the ULK1 protein kinase complex. This protein complex also contains the adaptor proteins ATG (autophagy-related) 13, RB1CC1/FIP200 (RB1-inducible coiled-coil 1), and ATG101. The gene encoding this protein is localized on human chromosome 12q24.33.

应用

GST-ULK1 has been used in in vitro kinase assay.

生化/生理作用

Unc-51 like autophagy activating kinase 1 (ULK1) protein kinase plays a crucial role in the control of autophagy initiation. This protein is responsible for activating a cascade of signaling pathways which results in the formation of phagosomes. ULK1 is also required for the control of the expression of key interferon-stimulated genes (ISGs).

外形

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

制备说明

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

法律信息

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

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Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy
Stefan D
Autophagy (2015)
Computational analysis of an autophagy/translation switch based on mutual inhibition of MTORC1 and ULK1.
Szymanska Pp
PLoS ONE (2015)
Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy.
Driebren S
Autophagy (2015)
Edmond Y W Chan et al.
The Journal of biological chemistry, 282(35), 25464-25474 (2007-06-28)
Autophagy is a vital response to nutrient starvation. Here, we screened a kinase-specific siRNA library using an autophagy assay in human embryonic kidney 293 cells that measures lipidation of the marker protein GFP-LC3 following amino acid starvation. This screen identified
Missense Mutation in Pseudouridine Synthase 1 (PUS1) Causes Mitochondrial Myopathy and Sideroblastic Anemia (MLASA)
YelenaBykhovskaya
The American Journal on Addictions (2004)
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