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生物来源
human
重组
expressed in E. coli
方案
≥98% (SDS-PAGE)
表单
lyophilized
效能
150-300 ng/mL
分子量
~7.9 kDa
包装
pkg of 25 μg
杂质
endotoxin, tested
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... EPGN(255324)
一般描述
The precursor EPGN (epigen) is a transmembrane glycoprotein and is widely expressed in human tissues. The precursor is cleaved to give a soluble EGF (epidermal growth factor)-like domain.
Recombinant Human epigen, produced in Escherichia coli is a single, non-glycosylated, polypeptide chain containing 72 amino acids and having a molecular mass of 7.9kDa.
Recombinant Human epigen, produced in Escherichia coli is a single, non-glycosylated, polypeptide chain containing 72 amino acids and having a molecular mass of 7.9kDa.
生化/生理作用
EPGN (epigen) is a ligand for EGFR (epidermal growth factor receptor). EPGN (epigen) belongs to the EGF family and enhances proliferation in keratinocytes.
外形
EPGN was lyophilized from 20 mM PBS buffer pH-7.4 containing 130 mM sodium chloride.
重悬
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in sterile d-H2O not less than 100 μg/ml. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA).
法规信息
新产品
Fetal inhibition of inflammation improves disease phenotypes in harlequin ichthyosis.
Cottle DL, et al.
Human Molecular Genetics, 24, 436-436 (2015)
The EGFR-HER2 module: a stem cell approach to understanding a prime target and driver of solid tumors.
Schneider MR and Yarden Y
Oncogene, 35, 2949-2949 (2019)
Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity.
Kochupurakkal BS, et al.
The Journal of Biological Chemistry, 280, 8503-8503 (2005)
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