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生物来源
human
重组
expressed in E. coli
方案
≥98% (HPLC)
≥98% (SDS-PAGE)
表单
lyophilized
分子量
~9.8 kDa
包装
pkg of 50 μg
储存条件
avoid repeated freeze/thaw cycles
杂质
endotoxin, tested
NCBI登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... PTHLH(5744)
一般描述
Parathyroid Hormone-like related Protein (PTHrP) is a member of the Parathyroid hormone family that is expressed in the mammary gland. It is known as a potent inhibitor of chondrocyte maturation. PTHrP is expressed by periarticular perichondrial cells and exerts its biological activity on PP-R expressing cells. During endochondral bone development PTHrP plays a major role in suppressing the onset of hypertrophic differentiation. It is also responsible for most cases of humoral hypercalcemia of malignancy. Recombinant Human PTHrP is a 9.8 kDa protein consisting of 86 amino acid residues.
Recombinant Human PTHrP is a 9.8 kDa protein consisting of 86 amino acid residues.
应用
The human parathyroid hormone-like related protein (PTHrP) has been used as an osteoarthritis-associated factor regulating hypertrophic differentiation of human chondrocytes. It has also been used in the regulation of the expression of Smpd3 (Sphingomyelin phosphodiesterase 3) in chondrocytes.
生化/生理作用
The gene PTHrP (parathyroid hormone-like related protein) encodes a protein involved in skeletal development. It binds to the receptor activated by PTH (parathyroid hormone) and functions in smooth muscle relaxation, regulation of cellular proliferation and differentiation. It also regulates endochondral bone development and proliferation of growth plate chondrocytes. It regulates fetal blood calcium and placental calcium transport. It has been associated with malignant hypercalcemia. Mutation in this gene has been associated with brachydactyly type E2 (BDE2).
外形
Sterile filtered and lyophilized without additives.
重悬
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
历史批次信息供参考:
Smpd3 Expression in both Chondrocytes and Osteoblasts Is Required for Normal Endochondral Bone Development.
Li J
Molecular and Cellular Biology, 36, 2282-2299 (2016)
Exome sequencing reveals a novel PTHLH mutation in a Chinese pedigree with brachydactyly type E and short stature.
Wang J
Clinica Chimica Acta; International Journal of Clinical Chemistry, 446:9-44614 (2015)
Huiren Tao et al.
PloS one, 6(8), e23199-e23199 (2011-09-03)
p38 mitogen-activated protein kinase (MAPK) acts downstream in the signaling pathway that includes receptor activator of NF-κB (RANK), a powerful inducer of osteoclast formation and activation. We investigated the role of p38 MAPK in parathyroid hormone related protein (PTHrP)-induced osteoclastogenesis
PTHrP and skeletal development.
Kronenberg HM
Annals of the New York Academy of Sciences, 1068, 1-13 (2006)
The cytology of the gametes and fertilization of Allomyces macrogynus.
Pommerville J and Fuller MS
Archives of Microbiology, 109, 21-30 (1976)
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