推荐产品
生物来源
human
重组
expressed in E. coli
方案
≥90% (SDS-PAGE)
表单
lyophilized
分子量
15-16 kDa
包装
pkg of 10 μg
储存条件
avoid repeated freeze/thaw cycles
杂质
endotoxin, tested
NCBI登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... VEGFC(7424)
一般描述
The recombinant VEGF-C (vascular endothelial growth factor-C) is a 125 amino acid protein that lacks the N-terminal signal peptide (from T103 to R227 of Gene Bank U58111). Human VEGF-C exhibits about 85% homology with mouse VEGF-C. The VEGFC gene is mapped to human chromosome 4q34.3.
应用
VEGF-C human has been used to determine cell proliferation and survival.
生化/生理作用
VEGF-C (vascular endothelial growth factor-C) promotes tumorigenesis, by inducing lymphatic metastasis. The production of VEGF-C is stimulated by pro-fibrotic transforming growth factor β. The main function of VEGF-C is to mediate lymphangiogenesis. Overexpression of VEGF-C in keratinocytes of skin causes dermal lymphatic vessel hyperplasia.
外形
Lyophilized without additives.
重悬
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/mL.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Tumor necrosis factor superfamily 15 promotes lymphatic metastasis via upregulation of vascular endothelial growth factor-C in a mouse model of lung cancer
Qin T, et al.
Cancer Science, 109(8), 2469-2469 (2018)
Connective tissue growth factor regulates fibrosis-associated renal lymphangiogenesis
Kinashi H, et al.
Kidney International, 92(4), 850-863 (2017)
Angiogenesis: From Basic Science to Clinical Applications, 58-58 (2006)
The effect of vascular endothelial growth factor in the progression of bladder cancer and diabetic retinopathy
Aldebasi YH, et al.
International Journal of Clinical and Experimental Medicine, 6(4), 239-239 (2013)
Kazuhide Hayakawa et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(29), 10666-10670 (2011-07-22)
Originally identified as an angiogenic factor, vascular endothelial growth factor (VEGF-A) is now known to play multiple roles in the CNS, including the direct regulation of neuronal and astrocytic functions. Here, we ask whether VEGF-A can also have a novel
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