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生物来源
human
重组
expressed in E. coli
方案
≥98% (SDS-PAGE)
表单
lyophilized
分子量
~19 kDa
包装
pkg of 100 μg
储存条件
avoid repeated freeze/thaw cycles
杂质
endotoxin, tested
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... FABP3(2170)
一般描述
Fatty acid binding proteins (FABPs) are intracellular proteins with a low molecular weight. They exhibit high affinity for small lipophilic ligands. FABP-3 is expressed in the skeletal muscle, heart, brain and brown adipose tissue. The gene encoding it is localized on human chromosome 1p35.
生化/生理作用
Studies suggest that fatty acid binding protein (FABPs) are involved in the uptake and metabolism of fatty acids, maintenance of cellular membrane fatty acids levels, intracellular trafficking, modulation of specific enzymes of lipid metabolic pathways, as well as in the modulation of cell growth and differentiation. FABPs have been associated with diabetes, obesity, atherosclerosis and brain function. FABP-3 has a role in glucose and lipid metabolism. It also modulates polysaturated fatty acid uptake and metabolism in neurons. The protein has been associated with schizophrenia, Down′s syndrome, Alzheimer′s disease and autism spectrum disorder.
外形
Sterile filtered and Lyophilized without additives.
重悬
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Keren Kang et al.
Scandinavian journal of clinical and laboratory investigation, 75(8), 693-698 (2015-10-02)
To develop a rapid, sensitive and specific assay for quantification of serum heart-type fatty acid binding protein (H-FABP) based on immunofluorescence of specific monoclonal antibodies. We generated novel H-FABP-directed monoclonal antibodies by cloning of spleen cells of mice immunized with
Ondrej Libiger et al.
Alzheimer's & dementia : the journal of the Alzheimer's Association, 17(12), 1976-1987 (2021-05-14)
Biomarkers that reflect pathologic processes affecting neuronal function during preclinical and early stages of Alzheimer's disease (AD) are needed to aid drug development. A targeted, stable isotope, quantitative mass spectrometry-based investigation of longitudinal changes in concentrations of previously identified candidate
Accelerated expansion of group IID-like phospholipase A2 genes in Bos taurus.
Golik M
Genomics, 87(4), 527-533 (2006)
Tatsuya Kusudo et al.
FEBS letters, 589(18), 2382-2387 (2015-07-25)
Fatty acid-binding proteins (FABP) play a crucial role in intracellular fatty acid transportation and metabolism. In this study, we investigate the effects of the FABP3 Asp3Gly (D3G) polymorphism on protein structure and function. Although the mutation did not alter protein
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