SRP4364
VEGF165 from mouse
recombinant, expressed in E. coli
别名:
MGC70609, VEGF, VEGF-A, VPF, Vascular endothelial growth factor A, Vascular permeability factor
biological source
mouse
recombinant
expressed in E. coli
assay
≥98%
form
lyophilized
potency
1.0-5 ng/mL
mol wt
~39.0 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Vegfa(22339)
General description
VEGF (vascular endothelial growth factor) is a homodimeric protein secreted by a variety of vascularized tissues. It is expressed embryonically in mice, in the lung mesenchyme and epithelium. It belongs to the group of vascular endothelium-specific growth factors. Mouse VEGF is a 39kDa homodimeric protein consisting of two 165 amino acid polypeptide chains.
Biochem/physiol Actions
VEGF (vascular endothelial growth factor) stimulates endothelial cell growth, angiogenesis, vasculogenesis and capillary permeability. It has a role in the differentiation of mesenchymal stem cells into osteoblasts and adipocytes. Disruption of this gene in mice has been associated with vascular abnormalities.
Physical form
Lyophilized without any additives.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Vascular Endothelial Growth Factor (VEGF) Bioavailability Regulates Angiogenesis and Intestinal Stem and Progenitor Cell Proliferation during Postnatal Small Intestinal Development.
Schlieve CR
PLoS ONE, 11(3), e0151396-e0151396 (2016)
Sequestration of Vascular Endothelial Growth Factor (VEGF) Induces Late Restrictive Lung Disease.
Wieck MM
PLoS ONE, 11(2), e0148323-e0148323 (2016)
Vascular-specific growth factors and blood vessel formation.
Yancopoulos GD
Nature, 407(6801), 242-248 (2000)
Anti-bevacizumab idiotype antibody vaccination is effective in inducing vascular endothelial growth factor-binding response, impairing tumor outgrowth.
Sanches Jde S
Cancer Science, 107(4), 551-555 (2016)
Zhen Lu et al.
Nature communications, 13(1), 6623-6623 (2022-11-06)
Activities of dendritic cells (DCs) that present tumor antigens are often suppressed in tumors. Here we report that this suppression is induced by tumor microenvironment-derived factors, which activate the activating transcription factor-3 (ATF3) transcription factor and downregulate cholesterol 25-hydroxylase (CH25H).
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