生物来源
human
重组
expressed in E. coli
检测方案
≥98% (HPLC)
≥98% (SDS-PAGE)
形式
lyophilized
效能
1.0-7.0 ng/mL
分子量
~38.2 kDa
包装
pkg of 10 μg
储存条件
avoid repeated freeze/thaw cycles
杂质
endotoxin, tested
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... VEGFA(7422)
一般描述
The gene VEGFA (vascular endothelial growth factor A) is a member of VEGF family of growth factors. The gene is localized to human chromosome 6p21.1. It contains eight exons interspaced by seven introns, spanning a length of 14 kb. The critical region of 2.36 kbp in human promoter lacks a consensus TATA box. However, it contains various consensus-binding sites for many transcriptional regulators.
生化/生理作用
The gene VEGFA (vascular endothelial growth factor A) encodes a secreted mitogen that is found to participate in physiological and pathological angiogenesis. It serves as a growth factor for endothelial cells and functions in the formation of new blood vessels during embryonic development and adulthood. It binds to two tyrosine kinase receptors VEGFR1 and VEGFR2 and functions in angiogenesis and maintenance of vasculature.
外形
Lyophilized with no additives.
重悬
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Genetic variants on chromosome 6p21.1 and 6p22.3 are associated with type 2 diabetes risk: a case-control study in Han Chinese.
Lu F
Journal of Human Genetics, 57, 320-325 (2012)
Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors.
Lee S
The Journal of Cell Biology, 169, 681-691 (2005)
VEGFA is necessary for chondrocyte survival during bone development.
Zelzer E
Development, 131, 2161-2171 (2004)
Vivian Lehmann et al.
Biotechnology progress, 35(2), e2745-e2745 (2018-11-14)
The only cure available for Type 1 diabetes involves the transplantation of islets of Langerhans isolated from donor organs. However, success rates are relatively low. Disconnection from vasculature upon isolation and insufficient rate of revascularization upon transplantation are thought to
Vivian Lehmann et al.
Biotechnology progress, 35(2), e2745-e2745 (2018-11-14)
The only cure available for Type 1 diabetes involves the transplantation of islets of Langerhans isolated from donor organs. However, success rates are relatively low. Disconnection from vasculature upon isolation and insufficient rate of revascularization upon transplantation are thought to
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