推荐产品
生物来源
human
重组
expressed in E. coli
检测方案
≥99% (HPLC)
≥99% (SDS-PAGE)
形式
lyophilized
分子量
~7.6 kDa
包装
pkg of 10 μg
杂质
endotoxin, tested
NCBI登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... CCL4(388372)
一般描述
MIP-1β (macrophage inflammatory protein-1β), or CCL4L1 (C-C motif chemokine ligand 4 like 1), is a CC chemokine gene localized to human chromosome 17q12. It is a copy number variable gene which shares 95% sequence homology with its non-copy number variable paralogues CCL4. MIP-1β is expressed by a wide range of cells including immune cells, such as monocytes, B and T cells, fibroblasts, endothelial, and epithelial cells.
生化/生理作用
MIP-1β (macrophage inflammatory protein-1β), or CCL4L1 (C-C motif chemokine ligand 4 like 1), interacts with its major G protein-coupled receptors CCR5 and CCR8, and promotes the migration of immune cells, such as monocytes, natural killer (NK) cells, and T cells, maturation of dendritic cells (DCs), T cell and granulocyte activation, and T cell differentiation. It is an age associated inflammatory cytokine, and it shows elevated expression in the monocytes and blood of elderly individuals. MIP-1β plays a wide role in immune responses, and hence, its expression is tightly controlled during T-cell differentiation and activation.
外形
Lyophilized without any additives.
重悬
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.
法规信息
新产品
Evolution of haplotypes at CCL3L1/CCL4L1.
Genome Biology, P20 (2010)
Functional redundancy of the human CCL4 and CCL4L1 chemokine genes.
Biochemical and Biophysical Research Communications, 320(3), 927-931 (2004)
MicroRNA-125b modulates inflammatory chemokine CCL4 expression in immune cells and its reduction causes CCL4 increase with age.
Aging Cell, 14(2), 200-208 (2015)
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