推荐产品
生物来源
mouse
重组
expressed in E. coli
方案
≥98% (HPLC)
≥98% (SDS-PAGE)
表单
lyophilized
效能
<0.05 ng/mL ED50
分子量
~15.1 kDa
包装
pkg of 10 μg
杂质
endotoxin, tested
NCBI登记号
运输
wet ice
储存温度
−20°C
基因信息
mouse ... Il3(16187)
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相关类别
一般描述
IL3 (interleukin 3) is an immunomodulatory cytokine and a multilineage hematopoietic growth factor. It is predominantly produced by activated CD4+ T cells and mast cells. Recombinant mouse IL-3 is a 15.1 kDa protein containing 135 amino acid residues.
生化/生理作用
IL3 (interleukin 3) was originally known as multicolony-stimulating factor due to its capability to promote the development of a wide variety of hematopoietic progenitor cells from bone marrow, such as basophils, neutrophils, eosinophils, erythrocytes, megakaryocytes, mast cells, macrophages, and dendritic cells. In vitro this protein facilitates murine hematopoietic progenitor cell differentiation, and the survival and activation of mature myeloid cells. It promotes the release of histamine and mast cell growth, differentiation, and mediator release, and hence, is implicated in allergic inflammation. It exhibits bi-functionality during osteoclastogenesis where it stimulates the development of osteoclast progenitors but suppresses the osteoclastogenic process. Certain variants in this gene confer protection against malaria attack, and thus, this gene might play a role in the pathophysiology of falciparum malaria.
外形
Sterile filtered and lyophilized with no additives.
重悬
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1 –1.0 mg/mL. The solution can then be diluted into other aqueous buffers.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
IL3 variant on chromosomal region 5q31-33 and protection from recurrent malaria attacks.
Meyer CG, et al.
Human Molecular Genetics, 20(6), 1173-1181 (2011)
Interleukin-3-deficient mice have increased resistance to blood-stage malaria.
Auclair SR et al
Infection and Immunity, 82(3), 1308-1314 (2014)
Serena De Vita et al.
PloS one, 9(5), e96209-e96209 (2014-05-03)
Systemic Mastocytosis (SM) is a clonal disease characterized by abnormal accumulation of mast cells in multiple organs. Clinical presentations of the disease vary widely from indolent to aggressive forms, and to the exceedingly rare mast cell leukemia. Current treatment of
Jing Wang et al.
EMBO molecular medicine, 6(7), 952-969 (2014-06-26)
Immunoglobulin E (IgE) activates mast cells (MCs). It remains unknown whether IgE also activates other inflammatory cells, and contributes to the pathogenesis of abdominal aortic aneurysms (AAAs). This study demonstrates that CD4+ T cells express IgE receptor FcεR1, at much
Huixian Hong et al.
Biochemical and biophysical research communications, 440(4), 545-550 (2013-10-10)
Interleukin (IL)-3, a multilineage hematopoietic growth factor, is implicated in the regulation of osteoclastogenesis. However, the role of IL-3 in osteoclastogenesis remains controversial; whereas early studies showed that IL-3 stimulates osteoclastogenesis, recent investigations demonstrated that IL-3 inhibits osteoclast formation. The
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