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Merck
CN
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主要文件

安全信息

SRP4053

Sigma-Aldrich

FGF-8 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

别名:

AIGF, FGF-8b, FGF8, Fibroblast Growth Factor-8, HBGF

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About This Item

MDL编号:
MFCD01867043
UNSPSC代码:
12352202
NACRES:
NA.32

生物来源

human

重组

expressed in E. coli

方案

≥95% (SDS-PAGE)

表单

lyophilized

效能

≥2x10^6 units/mg

分子量

~22.4 kDa

包装

pkg of 25 μg

储存条件

avoid repeated freeze/thaw cycles

杂质

endotoxin, tested

NCBI登记号

NM_006119

UniProt登记号

P55075

运输

wet ice

储存温度

−20°C

基因信息

human ... FGF8(2253)

一般描述

Fibroblast growth factor-8 (FGF-8) is also known as androgen-induced growth factor (AIGF). It is a heparin-binding growth factor. The gene encoding this protein is localized on human chromosome 10. Recombinant human FGF-8 is a 22.4kDa protein containing 193 amino acid residues.

生化/生理作用

Fibroblast growth factor-8 (FGF-8) stimulates the proliferation and activation of cells that express the FGF receptors. It has a role in embryogenesis. FGF8b, an isoform of FGF-8, is expressed in prostate cancer.

外形

Lyophilized in 10 mM Tris, pH 8.0 plus 75 mM NaCl. The protein may appear as a haze or film, which may not be seen at the bottom of the vial.

重悬

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in 5 mM Tris, pH 8.0 to a concentration of 0.1-1 mg/mL. This solution can be diluted into other aqueous buffers.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
5J11L40530
50953
60253

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Karolina Jendryczko et al.
Frontiers in pharmacology, 12, 748936-748936 (2021-12-07)
Targeted therapies are a promising alternative to conventional chemotherapy, with an increasing number of therapeutics targeting specific molecular aberrancies in cancer cells. One of the emerging targets for directed cancer treatments is fibroblast growth factor receptors (FGFRs), which are known
A novel locus of ectodermal dysplasia maps to chromosome 10q24.32-q25.1.
Rafiq MA
The Journal of Investigative Dermatology, 124(2), 338-342 (2005)
Screening a phage display library for a novel FGF8b-binding peptide with anti-tumor effect on prostate cancer.
Wang W
Experimental Cell Research, 319(8), 1156-1164 (2013)

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