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生物来源
human
重组
expressed in E. coli
检测方案
≥95% (SDS-PAGE)
形式
lyophilized
效能
≥2x10^6 units/mg
分子量
~22.4 kDa
包装
pkg of 25 μg
储存条件
avoid repeated freeze/thaw cycles
杂质
endotoxin, tested
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... FGF8(2253)
一般描述
Fibroblast growth factor-8 (FGF-8) is also known as androgen-induced growth factor (AIGF). It is a heparin-binding growth factor. The gene encoding this protein is localized on human chromosome 10. Recombinant human FGF-8 is a 22.4kDa protein containing 193 amino acid residues.
生化/生理作用
Fibroblast growth factor-8 (FGF-8) stimulates the proliferation and activation of cells that express the FGF receptors. It has a role in embryogenesis. FGF8b, an isoform of FGF-8, is expressed in prostate cancer.
外形
Lyophilized in 10 mM Tris, pH 8.0 plus 75 mM NaCl. The protein may appear as a haze or film, which may not be seen at the bottom of the vial.
重悬
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in 5 mM Tris, pH 8.0 to a concentration of 0.1-1 mg/mL. This solution can be diluted into other aqueous buffers.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Karolina Jendryczko et al.
Frontiers in pharmacology, 12, 748936-748936 (2021-12-07)
Targeted therapies are a promising alternative to conventional chemotherapy, with an increasing number of therapeutics targeting specific molecular aberrancies in cancer cells. One of the emerging targets for directed cancer treatments is fibroblast growth factor receptors (FGFRs), which are known
Screening a phage display library for a novel FGF8b-binding peptide with anti-tumor effect on prostate cancer.
Wang W
Experimental Cell Research, 319(8), 1156-1164 (2013)
A novel locus of ectodermal dysplasia maps to chromosome 10q24.32-q25.1.
Rafiq MA
The Journal of Investigative Dermatology, 124(2), 338-342 (2005)
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